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2017 ; 9
(5
): ä Nephropedia Template TP
gab.com Text
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English Wikipedia
African Swine Fever Virus: A Review
#MMPMID28489063
Galindo I
; Alonso C
Viruses
2017[May]; 9
(5
): ä PMID28489063
show ga
African swine fever (ASF) is a highly contagious viral disease of swine which
causes high mortality, approaching 100%, in domestic pigs. ASF is caused by a
large, double stranded DNA virus, ASF virus (ASFV), which replicates
predominantly in the cytoplasm of macrophages and is the only member of the
Asfarviridae family, genus Asfivirus. The natural hosts of this virus include
wild suids and arthropod vectors of the Ornithodoros genus. The infection of ASFV
in its reservoir hosts is usually asymptomatic and develops a persistent
infection. In contrast, infection of domestic pigs leads to a lethal hemorrhagic
fever for which there is no effective vaccine. Identification of ASFV genes
involved in virulence and the characterization of mechanisms used by the virus to
evade the immune response of the host are recognized as critical steps in the
development of a vaccine. Moreover, the interplay of the viral products with host
pathways, which are relevant for virus replication, provides the basic
information needed for the identification of potential targets for the
development of intervention strategies against this disease.
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