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2016 ; 16
(8
): 1238-50
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Advancing translational research with next-generation protein microarrays
#MMPMID26749402
Yu X
; Petritis B
; LaBaer J
Proteomics
2016[Apr]; 16
(8
): 1238-50
PMID26749402
show ga
Protein microarrays are a high-throughput technology used increasingly in
translational research, seeking to apply basic science findings to enhance human
health. In addition to assessing protein levels, posttranslational modifications,
and signaling pathways in patient samples, protein microarrays have aided in the
identification of potential protein biomarkers of disease and infection. In this
perspective, the different types of full-length protein microarrays that are used
in translational research are reviewed. Specific studies employing these
microarrays are presented to highlight their potential in finding solutions to
real clinical problems. Finally, the criteria that should be considered when
developing next-generation protein microarrays are provided.