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2015 ; 27
(4
): 349-57
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Advances of stereotactic body radiotherapy in pancreatic cancer
#MMPMID26361404
Wei Q
; Yu W
; Rosati LM
; Herman JM
Chin J Cancer Res
2015[Aug]; 27
(4
): 349-57
PMID26361404
show ga
Pancreatic cancer (PCA) is one of the most aggressive tumors with few effective
treatment modalities. It is the 4th and 7th leading cause of cancer death in the
United States and China, respectively. At the time of diagnosis, only 20% of
cases present with a resectable tumor, and about 40% with a locally advanced
tumor that is considered unresectable. Even resected patients still have a poor
prognosis, with an incidence of local recurrence ranging from 20% to 60%. It is
also reported that up to 30% of PCA patients die from locally obstructive disease
with few or no distant metastases. These findings have highlighted the importance
of local radiation therapy in the treatment of PCA. As the role of conventional
chemoradiotherapy remains controversial, the dawn of the pancreas stereotactic
body radiation therapy (SBRT) era represents a potential paradigm shift in the
management of PCA. SBRT delivers a higher biological effective dose to the tumor
with sharp dose escalation in a shorter treatment time course. Pancreas SBRT is a
novel therapeutic option to achieve local tumor control with minimal toxicity.
Herein, we review the advancement of SBRT for PCA patients with different stages
of pancreatic adenocarcinoma.