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10.1111/bjh.12725 http://scihub22266oqcxt.onion/10.1111/bjh.12725 C4381431!4381431 !24405087     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24405087 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24405087 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Br+J+Haematol 2014 ; 164 (6 ): 767-78 Nephropedia Template TP {{tp|p=24405087 |t=2014. Advances in understanding the leukaemia microenvironment |pdf=|usr=}}{{24405087 }} gab.com Text Advances in understanding the leukaemia microenvironment JO: Br J Haematol http://www.kidney.de/pget.php?&tw=1&pmid=24405087 #FOAvip Dynamic interactions between leukaemic cells and cells of the bone marrow are a feature of haematological malignancies. Two distinct microenvironmental niches in the bone marrow, the 'osteoblastic (endosteal)' and 'vascular' niches, provide a sanctuary for subpopulations of leukaemic cells to evade chemotherapy-induced death and allow acquisition of drug resistance. Key components of the bone marrow microenvironment as a home for normal haematopoietic stem cells and the leukaemia stem cell niches, and the molecular pathways critical for microenvironment/leukaemia interactions via cytokines, chemokines and adhesion molecules as well as hypoxic conditions, are described in this review. Finally, the genetic abnormalities of leukaemia-associated stroma are discussed. Further understanding of the contribution of the bone marrow niche to the process of leukaemogenesis may provide new targets that allow destruction of leukaemia stem cells without adversely affecting normal stem cell self-renewal. Twit Text FOAVip Advances in understanding the leukaemia microenvironment ????Br J Haematol http://www.kidney.de/pget.php?&tw=1&pmid=24405087 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24405087 #FOAvip English Wikipedia <ref>{{Cite pmid|24405087 }}</ref> Advances in understanding the leukaemia microenvironment #MMPMID24405087 Tabe Y ; Konopleva M Br J Haematol 2014[Mar]; 164 (6 ): 767-78 PMID24405087 show ga Dynamic interactions between leukaemic cells and cells of the bone marrow are a feature of haematological malignancies. Two distinct microenvironmental niches in the bone marrow, the 'osteoblastic (endosteal)' and 'vascular' niches, provide a sanctuary for subpopulations of leukaemic cells to evade chemotherapy-induced death and allow acquisition of drug resistance. Key components of the bone marrow microenvironment as a home for normal haematopoietic stem cells and the leukaemia stem cell niches, and the molecular pathways critical for microenvironment/leukaemia interactions via cytokines, chemokines and adhesion molecules as well as hypoxic conditions, are described in this review. Finally, the genetic abnormalities of leukaemia-associated stroma are discussed. Further understanding of the contribution of the bone marrow niche to the process of leukaemogenesis may provide new targets that allow destruction of leukaemia stem cells without adversely affecting normal stem cell self-renewal. |*Tumor Microenvironment [MESH] |Animals [MESH] |Humans [MESH] |Leukemia/metabolism/*pathology [MESH]Advances in understanding the leukaemia microenvironment (epmc).pdf DeepDyve Pubget Overpricing