Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28299199
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28299199
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 F1000Res
2017 ; 6
(ä): 178
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Advances in understanding hypopituitarism
#MMPMID28299199
Stieg MR
; Renner U
; Stalla GK
; Kopczak A
F1000Res
2017[]; 6
(ä): 178
PMID28299199
show ga
The understanding of hypopituitarism has increased over the last three years.
This review provides an overview of the most important recent findings. Most of
the recent research in hypopituitarism has focused on genetics. New diagnostic
techniques like next-generation sequencing have led to the description of
different genetic mutations causative for congenital dysfunction of the pituitary
gland while new molecular mechanisms underlying pituitary ontogenesis have also
been described. Furthermore, hypopituitarism may occur because of an impairment
of the distinctive vascularization of the pituitary gland, especially by
disruption of the long vessel connection between the hypothalamus and the
pituitary. Controversial findings have been published on post-traumatic
hypopituitarism. Moreover, autoimmunity has been discussed in recent years as a
possible reason for hypopituitarism. With the use of new drugs such as
ipilimumab, hypopituitarism as a side effect of pharmaceuticals has come into
focus. Besides new findings on the pathomechanism of hypopituitarism, there are
new diagnostic tools in development, such as new growth hormone stimulants that
are currently being tested in clinical trials. Moreover, cortisol measurement in
scalp hair is a promising tool for monitoring cortisol levels over time.
free
free
free
