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Advances in on-chip vascularization
#MMPMID28318376
Haase K
; Kamm RD
Regen Med
2017[Apr]; 12
(3
): 285-302
PMID28318376
show ga
Microfluidics is invaluable for studying microvasculature, development of
organ-on-chip models and engineering microtissues. Microfluidic design can
cleverly control geometry, biochemical gradients and mechanical stimuli, such as
shear and interstitial flow, to more closely mimic in vivo conditions. In vitro
vascular networks are generated by two distinct approaches: via endothelial-lined
patterned channels, or by self-assembled networks. Each system has its own
benefits and is amenable to the study of angiogenesis, vasculogenesis and cancer
metastasis. Various techniques are employed in order to generate rapid perfusion
of these networks within a variety of tissue and organ-mimicking models, some of
which have shown recent success following implantation in vivo. Combined with
tuneable hydrogels, microfluidics holds great promise for drug screening as well
as in the development of prevascularized tissues for regenerative medicine.
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