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2015 ; 27
(5
): 440-7
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Advances in lupus genetics
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Curr Opin Rheumatol
2015[Sep]; 27
(5
): 440-7
PMID26218512
show ga
PURPOSE OF REVIEW: The field of systemic lupus erythematosus (SLE) genetics has
been advancing rapidly in recent years. This review will summarize recent
advances in SLE genetics. RECENT FINDINGS: Genome-wide-association and follow-up
studies have greatly expanded the list of associated polymorphisms, and much
current work strives to integrate these polymorphisms into immune system biology
and the pathogenic mediators involved in the disease. This review covers some
current areas of interest, including genetic studies in non-European SLE patient
populations, studies of pathogenic immune system subphenotypes such as type I
interferon and autoantibodies, and a rapidly growing body of work investigating
the functional consequences of the genetic polymorphisms associated with SLE.
SUMMARY: These studies provide a fascinating window into human SLE disease
biology. As the work proceeds from genetic association signal to altered human
biology, we move closer to tailoring interventions based upon an individual's
genetic substrate.