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2015 ; 14
(ä): 33-47
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Advances in hepatic stem/progenitor cell biology
#MMPMID26600740
Verhulst S
; Best J
; van Grunsven LA
; Dollé L
EXCLI J
2015[]; 14
(ä): 33-47
PMID26600740
show ga
The liver is famous for its strong regenerative capacity, employing different
modes of regeneration according to type and extent of injury. Mature liver cells
are able to proliferate in order to replace the damaged tissue allowing the
recovery of the parenchymal function. In more severe scenarios hepatocytes are
believed to arise also from a facultative liver progenitor cell compartment. In
human, severe acute liver failure and liver cirrhosis are also both important
clinical targets in which regeneration is impaired, where the role of this stem
cell compartment seems more convincing. In animal models, the current state of
ambiguity regarding the identity and role of liver progenitor cells in liver
physiology dampens the enthusiasm for the potential use of these cells in
regenerative medicine. The aim of this review is to give the basics of liver
progenitor cell biology and discuss recent results vis-ŕ-vis their identity and
contribution to liver regeneration.
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