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10.1093/jmcb/mjw014 http://scihub22266oqcxt.onion/10.1093/jmcb/mjw014 C4816150!4816150 !26993044     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26993044 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Mol+Cell+Biol 2016 ; 8 (2 ): 101-9 Nephropedia Template TP {{tp|p=26993044 |t=2016. Adiponectin signaling and function in insulin target tissues |pdf=|usr=}}{{26993044 }} gab.com Text Adiponectin signaling and function in insulin target tissues JO: J Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26993044 #FOAvip Obesity-linked type 2 diabetes is one of the paramount causes of morbidity and mortality worldwide, posing a major threat on human health, productivity, and quality of life. Despite great progress made towards a better understanding of the molecular basis of diabetes, the available clinical counter-measures against insulin resistance, a defect that is central to obesity-linked type 2 diabetes, remain inadequate. Adiponectin, an abundant adipocyte-secreted factor with a wide-range of biological activities, improves insulin sensitivity in major insulin target tissues, modulates inflammatory responses, and plays a crucial role in the regulation of energy metabolism. However, adiponectin as a promising therapeutic approach has not been thoroughly explored in the context of pharmacological intervention, and extensive efforts are being devoted to gain mechanistic understanding of adiponectin signaling and its regulation, and reveal therapeutic targets. Here, we discuss tissue- and cell-specific functions of adiponectin, with an emphasis on the regulation of adiponectin signaling pathways, and the potential crosstalk between the adiponectin and other signaling pathways involved in metabolic regulation. Understanding better just why and how adiponectin and its downstream effector molecules work will be essential, together with empirical trials, to guide us to therapies that target the root cause(s) of type 2 diabetes and insulin resistance. Twit Text FOAVip Adiponectin signaling and function in insulin target tissues ????J Mol Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=26993044 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26993044 #FOAvip English Wikipedia <ref>{{Cite pmid|26993044 }}</ref> Adiponectin signaling and function in insulin target tissues #MMPMID26993044 Ruan H ; Dong LQ J Mol Cell Biol 2016[Apr]; 8 (2 ): 101-9 PMID26993044 show ga Obesity-linked type 2 diabetes is one of the paramount causes of morbidity and mortality worldwide, posing a major threat on human health, productivity, and quality of life. Despite great progress made towards a better understanding of the molecular basis of diabetes, the available clinical counter-measures against insulin resistance, a defect that is central to obesity-linked type 2 diabetes, remain inadequate. Adiponectin, an abundant adipocyte-secreted factor with a wide-range of biological activities, improves insulin sensitivity in major insulin target tissues, modulates inflammatory responses, and plays a crucial role in the regulation of energy metabolism. However, adiponectin as a promising therapeutic approach has not been thoroughly explored in the context of pharmacological intervention, and extensive efforts are being devoted to gain mechanistic understanding of adiponectin signaling and its regulation, and reveal therapeutic targets. Here, we discuss tissue- and cell-specific functions of adiponectin, with an emphasis on the regulation of adiponectin signaling pathways, and the potential crosstalk between the adiponectin and other signaling pathways involved in metabolic regulation. Understanding better just why and how adiponectin and its downstream effector molecules work will be essential, together with empirical trials, to guide us to therapies that target the root cause(s) of type 2 diabetes and insulin resistance. |*Organ Specificity [MESH] |Adiponectin/*metabolism [MESH] |Animals [MESH] |Humans [MESH] |Insulin/*metabolism [MESH] |Models, Biological [MESH] |Receptors, Adiponectin/metabolism [MESH]Adiponectin signaling and function in insulin target tissues (epmc).pdf DeepDyve Pubget Overpricing