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2016 ; 9
(3
): 359-73
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Adipocytokines in renal transplant recipients
#MMPMID27274819
Nagy K
; Nagaraju SP
; Rhee CM
; Mathe Z
; Molnar MZ
Clin Kidney J
2016[Jun]; 9
(3
): 359-73
PMID27274819
show ga
In the last two decades, perceptions about the role of body fat have changed.
Adipocytes modulate endocrine and immune homeostasis by synthesizing hundreds of
hormones, known as adipocytokines. Many studies have been investigating the
influences and effects of these adipocytokines and suggest that they are
modulated by the nutritional and immunologic milieu. Kidney transplant recipients
(KTRs) are a unique and relevant population in which the function of
adipocytokines can be examined, given their altered nutritional and immune status
and subsequent dysregulation of adipocytokine metabolism. In this review, we
summarize the recent findings about four specific adipocytokines and their
respective roles in KTRs. We decided to evaluate the most widely described
adipocytokines, including leptin, adiponectin, visfatin and resistin. Increasing
evidence suggests that these adipocytokines may lead to cardiovascular events and
metabolic changes in the general population and may also increase mortality and
graft loss rate in KTRs. In addition, we present findings on the
interrelationship between serum adipocytokine levels and nutritional and
immunologic status, and mechanisms by which adipocytokines modulate morbidity and
outcomes in KTRs.