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2014 ; 4
(3
): ä Nephropedia Template TP
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Adipocytes in skin health and disease
#MMPMID24591537
Rivera-Gonzalez G
; Shook B
; Horsley V
Cold Spring Harb Perspect Med
2014[Mar]; 4
(3
): ä PMID24591537
show ga
Adipocytes are intimately associated with the dermal compartment of the skin,
existing in a specialized dermal depot and displaying dynamic changes in size
during tissue homeostasis. However, the roles of adipocytes in cutaneous biology
and disease are not well understood. Traditionally, adipocytes within tissues
were thought to act as reservoirs of energy, as thermal, or as structural
support. In this review, we discuss recent studies revealing the cellular basis
of the dynamic development and regenerative capacity of dermal adipocytes
associated with the hair cycle and following injury. We discuss and speculate on
potential roles of dermal adipocytes in cutaneous biology with an emphasis on
communication during hair follicle growth and wound healing. Finally, we explore
how alterations in the dermal adipose tissue may support clinical manifestations
of cutaneous diseases such as lipodystrophy, obesity, and alopecia.