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10.1016/j.molcel.2014.10.011 http://scihub22266oqcxt.onion/10.1016/j.molcel.2014.10.011 C4378961!4378961 !25454948     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25454948 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25454948 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Cell 2014 ; 56 (5 ): 696-707 Nephropedia Template TP {{tp|p=25454948 |t=2014. Adenylation of maternally inherited microRNAs by Wispy |pdf=|usr=}}{{25454948 }} gab.com Text Adenylation of maternally inherited microRNAs by Wispy JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25454948 #FOAvip Early development depends heavily on accurate control of maternally inherited mRNAs, and yet it remains unknown how maternal microRNAs are regulated during maternal-to-zygotic transition (MZT). We here find that maternal microRNAs are highly adenylated at their 3' ends in mature oocytes and early embryos. Maternal microRNA adenylation is widely conserved in fly, sea urchin, and mouse. We identify Wispy, a noncanonical poly(A) polymerase, as the enzyme responsible for microRNA adenylation in flies. Knockout of wispy abrogates adenylation and results in microRNA accumulation in eggs, whereas overexpression of Wispy increases adenylation and reduces microRNA levels in S2 cells. Wispy interacts with Ago1 through protein-protein interaction, which may allow the effective and selective adenylation of microRNAs. Thus, adenylation may contribute to the clearance of maternally deposited microRNAs during MZT. Our work provides mechanistic insights into the regulation of maternal microRNAs and illustrates the importance of RNA tailing in development. Twit Text FOAVip Adenylation of maternally inherited microRNAs by Wispy ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25454948 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25454948 #FOAvip English Wikipedia <ref>{{Cite pmid|25454948 }}</ref> Adenylation of maternally inherited microRNAs by Wispy #MMPMID25454948 Lee M ; Choi Y ; Kim K ; Jin H ; Lim J ; Nguyen TA ; Yang J ; Jeong M ; Giraldez AJ ; Yang H ; Patel DJ ; Kim VN Mol Cell 2014[Dec]; 56 (5 ): 696-707 PMID25454948 show ga Early development depends heavily on accurate control of maternally inherited mRNAs, and yet it remains unknown how maternal microRNAs are regulated during maternal-to-zygotic transition (MZT). We here find that maternal microRNAs are highly adenylated at their 3' ends in mature oocytes and early embryos. Maternal microRNA adenylation is widely conserved in fly, sea urchin, and mouse. We identify Wispy, a noncanonical poly(A) polymerase, as the enzyme responsible for microRNA adenylation in flies. Knockout of wispy abrogates adenylation and results in microRNA accumulation in eggs, whereas overexpression of Wispy increases adenylation and reduces microRNA levels in S2 cells. Wispy interacts with Ago1 through protein-protein interaction, which may allow the effective and selective adenylation of microRNAs. Thus, adenylation may contribute to the clearance of maternally deposited microRNAs during MZT. Our work provides mechanistic insights into the regulation of maternal microRNAs and illustrates the importance of RNA tailing in development. |Animals [MESH] |Argonaute Proteins/*metabolism [MESH] |Cell Line [MESH] |Drosophila Proteins/genetics/*metabolism [MESH] |Drosophila melanogaster/*embryology/genetics/*growth & development [MESH] |Embryo, Nonmammalian [MESH] |Gene Expression Regulation, Developmental [MESH] |Gene Knockout Techniques [MESH] |MicroRNAs/*metabolism [MESH] |Molecular Sequence Data [MESH] |Oocytes/growth & development [MESH] |Poly A/*genetics [MESH]Adenylation of maternally inherited microRNAs by Wispy (epmc).pdf DeepDyve Pubget Overpricing