Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26184280
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Viruses
2015 ; 7
(7
): 3719-40
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Adenovirus 36 and Obesity: An Overview
#MMPMID26184280
Ponterio E
; Gnessi L
Viruses
2015[Jul]; 7
(7
): 3719-40
PMID26184280
show ga
There is an epidemic of obesity starting about 1980 in both developed and
undeveloped countries definitely associated with multiple etiologies. About 670
million people worldwide are obese. The incidence of obesity has increased in all
age groups, including children. Obesity causes numerous diseases and the
interaction between genetic, metabolic, social, cultural and environmental
factors are possible cofactors for the development of obesity. Evidence emerging
over the last 20 years supports the hypothesis that viral infections may be
associated with obesity in animals and humans. The most widely studied infectious
agent possibly linked to obesity is adenovirus 36 (Adv36). Adv36 causes obesity
in animals. In humans, Adv36 associates with obesity both in adults and children
and the prevalence of Adv36 increases in relation to the body mass index. In vivo
and in vitro studies have shown that the viral E4orf1 protein (early region 4
open reading frame 1, Adv) mediates the Adv36 effect including its adipogenic
potential. The Adv36 infection should therefore be considered as a possible risk
factor for obesity and could be a potential new therapeutic target in addition to
an original way to understand the worldwide rise of the epidemic of obesity.
Here, the data indicating a possible link between viral infection and obesity
with a particular emphasis to the Adv36 will be reviewed.
free
free
free
