Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=19639291
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\19639291
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Handb+Exp+Pharmacol
2009 ; ä (193
): 443-70
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Adenosine receptors and the kidney
#MMPMID19639291
Vallon V
; Osswald H
Handb Exp Pharmacol
2009[]; ä (193
): 443-70
PMID19639291
show ga
The autacoid, adenosine, is present in the normoxic kidney and generated in the
cytosol as well as at extracellular sites. The rate of adenosine formation is
enhanced when the rate of ATP hydrolysis prevails over the rate of ATP synthesis
during increased tubular transport work or during oxygen deficiency.
Extracellular adenosine acts on adenosine receptor subtypes (A(1), A(2A), A(2B),
and A(3)) in the cell membranes to affect vascular and tubular functions.
Adenosine lowers glomerular filtration rate by constricting afferent arterioles,
especially in superficial nephrons, and thus lowers the salt load and transport
work of the kidney consistent with the concept of metabolic control of organ
function. In contrast, it leads to vasodilation in the deep cortex and the
semihypoxic medulla, and exerts differential effects on NaCl transport along the
tubular and collecting duct system. These vascular and tubular effects point to a
prominent role of adenosine and its receptors in the intrarenal metabolic
regulation of kidney function, and, together with its role in inflammatory
processes, form the basis for potential therapeutic approaches in radiocontrast
media-induced acute renal failure, ischemia reperfusion injury, and in patients
with cardiorenal failure.
free
free
free
