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10.1055/s-0034-1397352

http://scihub22266oqcxt.onion/10.1055/s-0034-1397352
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suck abstract from ncbi


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pmid25632938
      Semin+Liver+Dis 2015 ; 35 (1 ): 81-8
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  • Adeno-associated virus-mediated microRNA delivery and therapeutics #MMPMID25632938
  • Xie J ; Burt DR ; Gao G
  • Semin Liver Dis 2015[Feb]; 35 (1 ): 81-8 PMID25632938 show ga
  • MicroRNAs (miRNAs) are 20 to 24 nt long, single-stranded RNAs that repress gene expression. Dysregulation of miRNA expression is associated with many human diseases. Modulating the level of endogenous miRNA alters gene profiling and can achieve therapeutic benefits. Here the authors review currently used methods of altering miRNA activity in vivo. They focus on the delivery of miRNAs and miRNA inhibitors using recombinant adeno-associated virus (rAAV). In general, rAAV-mediated miRNA inhibition or overexpression provides a simple, efficient, and informative way to study miRNA function in mammals. This method also provides the opportunity to explore potential miRNA therapeutics for many diseases.
  • |Dependovirus [MESH]
  • |Gene Transfer Techniques [MESH]
  • |Genetic Therapy/*methods [MESH]
  • |Genetic Vectors [MESH]
  • |Humans [MESH]


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