Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.18632/oncotarget.11875 http://scihub22266oqcxt.onion/10.18632/oncotarget.11875 C5342165!5342165 !27608848     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27608848 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27608848 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (44 ): 72322-72342 Nephropedia Template TP {{tp|p=27608848 |t=2016. Addressing intra-tumoral heterogeneity and therapy resistance |pdf=|usr=}}{{27608848 }} gab.com Text Addressing intra-tumoral heterogeneity and therapy resistance JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27608848 #FOAvip In the last several years, our appreciation of intra-tumoral heterogeneity has greatly increased due to accumulating evidence for the co-existence of genetically and epigenetically divergent cancer cells residing in different microenvironments within a tumor. Herein, we review recent literature discussing intra-tumoral heterogeneity in the context of therapy resistance mechanisms at the genetic, epigenetic and microenvironmental levels. We illustrate the influence of tumor microenvironment on therapy resistance and epigenetic states of cancer cells by highlighting the role of cancer stem cells in therapy resistance. We also summarize different strategies that have been employed to address various resistance mechanisms at genetic, epigenetic, and microenvironmental levels in preclinical and clinical studies. We propose that future personalized cancer therapy design needs to incorporate dynamic and comprehensive analyses of tumor heterogeneity landscape and multi-dimensional mechanisms of therapy resistance. Twit Text FOAVip Addressing intra-tumoral heterogeneity and therapy resistance ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27608848 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27608848 #FOAvip English Wikipedia <ref>{{Cite pmid|27608848 }}</ref> Addressing intra-tumoral heterogeneity and therapy resistance #MMPMID27608848 Rybinski B ; Yun K Oncotarget 2016[Nov]; 7 (44 ): 72322-72342 PMID27608848 show ga In the last several years, our appreciation of intra-tumoral heterogeneity has greatly increased due to accumulating evidence for the co-existence of genetically and epigenetically divergent cancer cells residing in different microenvironments within a tumor. Herein, we review recent literature discussing intra-tumoral heterogeneity in the context of therapy resistance mechanisms at the genetic, epigenetic and microenvironmental levels. We illustrate the influence of tumor microenvironment on therapy resistance and epigenetic states of cancer cells by highlighting the role of cancer stem cells in therapy resistance. We also summarize different strategies that have been employed to address various resistance mechanisms at genetic, epigenetic, and microenvironmental levels in preclinical and clinical studies. We propose that future personalized cancer therapy design needs to incorporate dynamic and comprehensive analyses of tumor heterogeneity landscape and multi-dimensional mechanisms of therapy resistance. |*Genetic Heterogeneity [MESH] |Antineoplastic Agents/*pharmacology/therapeutic use [MESH] |Drug Resistance, Neoplasm/drug effects/*genetics [MESH] |Epigenesis, Genetic [MESH] |Humans [MESH] |Molecular Targeted Therapy/methods/*trends [MESH] |Mutation [MESH] |Neoplasms/drug therapy/*genetics/pathology [MESH] |Neoplastic Stem Cells/pathology [MESH] |Signal Transduction/genetics [MESH]Addressing intra-tumoral heterogeneity and therapy resistance (epmc).pdf DeepDyve Pubget Overpricing