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10.4161/21645515.2014.973318

http://scihub22266oqcxt.onion/10.4161/21645515.2014.973318
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suck abstract from ncbi


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pmid25483630
      Hum+Vaccin+Immunother 2014 ; 10 (11 ): 3306-12
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  • Adding fuel to the fire: immunogenic intensification #MMPMID25483630
  • O'Sullivan Coyne G ; Gulley JL
  • Hum Vaccin Immunother 2014[]; 10 (11 ): 3306-12 PMID25483630 show ga
  • The durable long term clinical benefits seen for certain patients treated with immunotherapy agents has suggested there is significant therapeutic potential to be derived from these agents, as shown by the increasing prominence of this treatment strategy in upcoming clinical trials. There has been a renewed interest and focus on the drivers of tumoral antigen recognition, and the pathways by which various cells of the immune system can stimulate, propagate and execute an effective anti-tumor response. Various challenges lie ahead in the further development of these treatments, including induction of an endogenous anti-tumor response, tumor microenvironment modulation, and T-cell response amplification. Novel treatment combinations may prove of significant added benefit by immunogenic intensification.
  • |Antibodies, Monoclonal/immunology/*therapeutic use [MESH]
  • |Antigens, Neoplasm/*immunology [MESH]
  • |Cancer Vaccines/immunology/*therapeutic use [MESH]
  • |Humans [MESH]
  • |Immunotherapy/*methods [MESH]
  • |Neoplasms/*immunology/therapy [MESH]
  • |T-Lymphocytes, Cytotoxic/immunology [MESH]


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