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2014 ; 10
(11
): 3306-12
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Adding fuel to the fire: immunogenic intensification
#MMPMID25483630
O'Sullivan Coyne G
; Gulley JL
Hum Vaccin Immunother
2014[]; 10
(11
): 3306-12
PMID25483630
show ga
The durable long term clinical benefits seen for certain patients treated with
immunotherapy agents has suggested there is significant therapeutic potential to
be derived from these agents, as shown by the increasing prominence of this
treatment strategy in upcoming clinical trials. There has been a renewed interest
and focus on the drivers of tumoral antigen recognition, and the pathways by
which various cells of the immune system can stimulate, propagate and execute an
effective anti-tumor response. Various challenges lie ahead in the further
development of these treatments, including induction of an endogenous anti-tumor
response, tumor microenvironment modulation, and T-cell response amplification.
Novel treatment combinations may prove of significant added benefit by
immunogenic intensification.
|Antibodies, Monoclonal/immunology/*therapeutic use
[MESH]
|Antigens, Neoplasm/*immunology
[MESH]
|Cancer Vaccines/immunology/*therapeutic use
[MESH]