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10.1016/j.cct.2015.06.007 http://scihub22266oqcxt.onion/10.1016/j.cct.2015.06.007 C4639447!4639447 !26079372     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26079372 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26079372 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Contemp+Clin+Trials 2015 ; 45 (Pt A ): 93-102 Nephropedia Template TP {{tp|p=26079372 |t=2015. Adaptive design of confirmatory trials: Advances and challenges |pdf=|usr=}}{{26079372 }} gab.com Text Adaptive design of confirmatory trials: Advances and challenges JO: Contemp Clin Trials http://www.kidney.de/pget.php?&tw=1&pmid=26079372 #FOAvip The past decade witnessed major developments in innovative designs of confirmatory clinical trials, and adaptive designs represent the most active area of these developments. We give an overview of the developments and associated statistical methods in several classes of adaptive designs of confirmatory trials. We also discuss their statistical difficulties and implementation challenges, and show how these problems are connected to other branches of mainstream Statistics, which we then apply to resolve the difficulties and bypass the bottlenecks in the development of adaptive designs for the next decade. Twit Text FOAVip Adaptive design of confirmatory trials: Advances and challenges ????Contemp Clin Trials http://www.kidney.de/pget.php?&tw=1&pmid=26079372 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26079372 #FOAvip English Wikipedia <ref>{{Cite pmid|26079372 }}</ref> Adaptive design of confirmatory trials: Advances and challenges #MMPMID26079372 Lai TL ; Lavori PW ; Tsang KW Contemp Clin Trials 2015[Nov]; 45 (Pt A ): 93-102 PMID26079372 show ga The past decade witnessed major developments in innovative designs of confirmatory clinical trials, and adaptive designs represent the most active area of these developments. We give an overview of the developments and associated statistical methods in several classes of adaptive designs of confirmatory trials. We also discuss their statistical difficulties and implementation challenges, and show how these problems are connected to other branches of mainstream Statistics, which we then apply to resolve the difficulties and bypass the bottlenecks in the development of adaptive designs for the next decade. |*Research Design [MESH] |Bayes Theorem [MESH] |Clinical Trials as Topic/economics/*methods/standards [MESH] |Clinical Trials, Phase II as Topic/methods [MESH] |Clinical Trials, Phase III as Topic/methods [MESH] |Computer Simulation [MESH] |Data Interpretation, Statistical [MESH] |Humans [MESH] |Sample Size [MESH] |United States [MESH]Adaptive design of confirmatory trials: Advances and challenges (epmc).pdf DeepDyve Pubget Overpricing