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10.1016/j.trim.2013.09.004

http://scihub22266oqcxt.onion/10.1016/j.trim.2013.09.004
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C5091013!5091013 !24056179
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suck abstract from ncbi


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pmid24056179
      Transpl+Immunol 2013 ; 29 (1-4 ): 114-7
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  • Acute transplant glomerulopathy with monocyte rich infiltrate #MMPMID24056179
  • Lenihan CR ; Tan JC ; Kambham N
  • Transpl Immunol 2013[Dec]; 29 (1-4 ): 114-7 PMID24056179 show ga
  • Acute transplant glomerulopathy refers to alloimmune mediated endothelial injury and glomerular inflammation that typically occurs early post-kidney transplantation. We report a case of a 48-year old woman with end stage renal disease from lupus nephritis who developed an unexplained rise in serum creatinine 2 months after renal transplant. As immunosuppression, she received alemtuzumab induction followed by a tacrolimus, mycophenolate mofetil and prednisone maintenance regimen. Her biopsy revealed severe glomerular endothelial injury associated with monocyte/macrophage-rich infiltrate in addition to mild acute tubulointerstitial cellular rejection. We briefly discuss acute transplant glomerulitis, its pathology and association with chronic/overt transplant glomerulopathy, C4d negative antibody-mediated rejection and the significance of monocytes in rejection. We also postulate that alemtuzumab induction may have contributed to the unusual pattern of monocyte-rich transplant glomerulitis.
  • |*Kidney Transplantation [MESH]
  • |Acute Disease [MESH]
  • |Allografts [MESH]
  • |Female [MESH]
  • |Glomerulonephritis, Membranous/*chemically induced/drug therapy/*pathology [MESH]
  • |Graft Rejection/*chemically induced/immunology/*pathology/prevention & control [MESH]
  • |Humans [MESH]
  • |Immunosuppressive Agents/administration & dosage/*adverse effects [MESH]
  • |Lupus Nephritis/immunology/pathology/surgery [MESH]
  • |Middle Aged [MESH]


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