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2018 ; 13
(1
): 69-75
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Acute pancreatitis in children
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Grzybowska-Chlebowczyk U
; Jasielska M
; Flak-Wancerz A
; Wi?cek S
; Gruszczy?ska K
; Chlebowczyk W
; Wo? H
Prz Gastroenterol
2018[]; 13
(1
): 69-75
PMID29657614
show ga
INTRODUCTION: The acute pancreatitis is a rare disease, but it has started to be
diagnosed more often in children. AIM: The aim of the study was single-centre,
retrospective analysis of the incidence, aetiology, and clinical course of acute
pancreatitis in children. MATERIAL AND METHODS: We analysed the medical records
of patients with acute pancreatitis hospitalised in the Gastroenterology Unit of
the Paediatrics Department, Medical University of Silesia from Jan 2004 to Dec
2013. RESULTS: There were 76 cases of acute pancreatitis among 51 children
(average age: 12.07 years) hospitalised in the Gastroenterology Unit between
January 2004 and December 2013. The diagnosis of acute pancreatitis was performed
on the basis of INSPIRE criteria and modified Atlanta classification. Patients
were divided into groups: I - 1-12 years old, which included 20 (39.21%) children
and II - 13-18 years old, with 31 (60.78%) children. The idiopathic aetiology was
the most common cause of acute pancreatitis, occurring in 22 (43.1%) children,
and in 15 cases the aetiology of the disease was biliary (29.4%). Genetically
determined causes were diagnosed in 8 (15.7%) patients, the PRSS1 mutation in
four patients, mutation in SPINK1 in 1 child, and CFTR gene mutation in 1 child.
Two children simultaneously had two genes mutations (CFTR, SPINK1), and during
the considered period had more than one episode of acute pancreatitis.
CONCLUSIONS: Acute pancreatitis of idiopathic aetiology was most common among the
examined children, and this should encourage the continued search for the causes
of disease, especially genetic, and with particular emphasis on younger age
group.
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