Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24848936
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24848936
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Opin+Nephrol+Hypertens
2014 ; 23
(4
): 385-90
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Acute and chronic kidney injury in nephrolithiasis
#MMPMID24848936
Tang X
; Lieske JC
Curr Opin Nephrol Hypertens
2014[Jul]; 23
(4
): 385-90
PMID24848936
show ga
PURPOSE OF REVIEW: Nephrolithiasis is a common systemic disease associated with
both acute kidney injury (AKI) and chronic kidney disease (CKD). The purpose of
this review is to discuss recent publications regarding
nephrolithiasis-associated kidney damage, with an emphasis on AKI. RECENT
FINDINGS: Nephrolithiasis is not a common cause of adult AKI (1-2% of cases),
although it may be a more important factor in young children (up to 30%). The
primary mechanism of nephrolithiasis-associated AKI is obstructive nephropathy,
and factors on presentation with obstructive uropathy predict the likelihood of
long-term renal recovery. Crystalline nephropathy is another potential pathway in
certain circumstances that is often associated with a worse outcome. Recent
studies have elucidated additional pathways whereby calcium oxalate crystals can
cause acute injury, implicating innate immunity and intracellular inflammasome
pathways. Several large cohort studies have demonstrated an independent
association of nephrolithiasis with CKD and end-stage renal disease, although the
effect size is modest. Urologic comorbidities, urinary infection, and shared
underlying risk factors (e.g., diabetes, hypertension) all impact
nephrolithiasis-associated CKD risk. SUMMARY: Obstructive nephropathy and
crystalline nephropathy both contribute to nephrolithiasis-associated AKI,
although the latter appears to have a worse prognosis. Nephrolithiasis is an
independent, albeit small, risk factor for CKD. Further study is needed to
clarify the incidence and mechanisms of nephrolithiasis-associated AKI, and the
relationship between nephrolithiasis-associated AKI and CKD.
free
free
free
