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2013 ; 50
(Suppl 1
): S26-S29
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Acute Treatment of Migraine
#MMPMID28360580
Öztürk V
Noro Psikiyatr Ars
2013[Aug]; 50
(Suppl 1
): S26-S29
PMID28360580
show ga
Migraine is one of the most frequent disabling neurological conditions with a
major impact on the patient's quality of life. Migraine has been described as a
chronic disorder that characterized with attacks. Attacks are characterized by
moderate-severe, often unilateral, pulsating headache attacks, typically lasting
4 to 72 hours. Migraine remains underdiagnosed and undertreated despite advances
in the understanding of its pathophysiology. This article reviews management of
migraine acute pharmacological treatment. Currently, for the acute treatment of
migraine attacks, non-steroidal anti-inflammatory drugs (NSAIDs) and triptans
(serotonin 5HT1B/1D receptor agonists) are recommended. Before intake of NSAID
and triptans, metoclopramide or domperidone is useful. In very severe attacks,
subcutaneous sumatriptan is first choice. The patient should be treated early in
the attack, use an adequate dose and formulation of a medication. Ideally, acute
therapy should be restricted to no more than 2 to 3 days per week to avoid
medication overuse.