Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25410656
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Genes+Immun
2015 ; 16
(2
): 170-5
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Activation of the JAK/STAT pathway in Behcet s disease
#MMPMID25410656
Tulunay A
; Dozmorov MG
; Ture-Ozdemir F
; Yilmaz V
; Eksioglu-Demiralp E
; Alibaz-Oner F
; Ozen G
; Wren JD
; Saruhan-Direskeneli G
; Sawalha AH
; Direskeneli H
Genes Immun
2015[Mar]; 16
(2
): 170-5
PMID25410656
show ga
Th1/Th17-type T-cell responses are upregulated in Behcet's disease (BD). However,
signaling pathways associated with this aberrant immune response are not
clarified. Whole-genome microarray profiling was performed with human U133 (Plus
2.0) chips using messenger RNA of isolated CD14(+) monocytes and CD4(+) T cells
from peripheral blood mononucleated cell (PBMC) in patients with BD (n = 9) and
healthy controls (HCs) (n = 9). Flow cytometric analysis of unstimulated (US) and
stimulated (phytohaemagglutinin) signal transducer and activator of transcription
(STAT3) and pSTAT3 expressions of PBMCs were also analyzed (BD and HC, both n =
26). Janus family of kinase (JAK1) was observed to be upregulated in both CD14(+)
monocytes (1.95-fold) and CD4(+) T lymphocytes (1.40-fold) of BD patients. Using
canonical pathway enrichment analysis, JAK/STAT signaling was identified as
activated in both CD14(+) monocytes (P = 9.55E-03) and in CD4(+) lymphocytes (P
=8.13E-04) in BD. Interferon signaling was also prominent among upregulated genes
in CD14(+) monocytes (P = 5.62E-05). Glucocorticoid receptor signaling and
interleukin (IL-6) signaling were among the most enriched pathways in
differentially expressed genes in CD14+ monocytes (P = 2.45E-09 and 1.00E-06,
respectively). Basal US total STAT3 expression was significantly higher in BD
(1.2 vs 3.45, P < 0.05). The JAK1/STAT3 signaling pathway is activated in BD,
possibly through the activation of Th1/Th17-type cytokines such as IL-2,
interferon (IFN-?), IL-6, IL-17 and IL-23.
free
free
free
