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10.1128/MMBR.00061-14 http://scihub22266oqcxt.onion/10.1128/MMBR.00061-14 C4429241!4429241 !25926682     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25926682 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25926682 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Microbiol+Mol+Biol+Rev 2015 ; 79 (2 ): 225-41 Nephropedia Template TP {{tp|p=25926682 |t=2015. Activation and regulation of DNA-driven immune responses |pdf=|usr=}}{{25926682 }} gab.com Text Activation and regulation of DNA-driven immune responses JO: Microbiol Mol Biol Rev http://www.kidney.de/pget.php?&tw=1&pmid=25926682 #FOAvip The innate immune system provides early defense against infections and also plays a key role in monitoring alterations of homeostasis in the body. DNA is highly immunostimulatory, and recent advances in this field have led to the identification of the innate immune sensors responsible for the recognition of DNA as well as the downstream pathways that are activated. Moreover, information on how cells regulate DNA-driven immune responses to avoid excessive inflammation is now emerging. Finally, several reports have demonstrated how defects in DNA sensing, signaling, and regulation are associated with susceptibility to infections or inflammatory diseases in humans and model organisms. In this review, the current literature on DNA-stimulated innate immune activation is discussed, and important new questions facing this field are proposed. Twit Text FOAVip Activation and regulation of DNA-driven immune responses ????Microbiol Mol Biol Rev http://www.kidney.de/pget.php?&tw=1&pmid=25926682 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25926682 #FOAvip English Wikipedia <ref>{{Cite pmid|25926682 }}</ref> Activation and regulation of DNA-driven immune responses #MMPMID25926682 Paludan SR Microbiol Mol Biol Rev 2015[Jun]; 79 (2 ): 225-41 PMID25926682 show ga The innate immune system provides early defense against infections and also plays a key role in monitoring alterations of homeostasis in the body. DNA is highly immunostimulatory, and recent advances in this field have led to the identification of the innate immune sensors responsible for the recognition of DNA as well as the downstream pathways that are activated. Moreover, information on how cells regulate DNA-driven immune responses to avoid excessive inflammation is now emerging. Finally, several reports have demonstrated how defects in DNA sensing, signaling, and regulation are associated with susceptibility to infections or inflammatory diseases in humans and model organisms. In this review, the current literature on DNA-stimulated innate immune activation is discussed, and important new questions facing this field are proposed. |Animals [MESH] |DNA/*immunology/*metabolism [MESH] |Humans [MESH] |Immune Evasion [MESH] |Immunity, Innate/*genetics [MESH] |Interferon Type I/genetics [MESH] |Membrane Proteins/metabolism [MESH] |Signal Transduction/genetics [MESH]Activation and regulation of DNA-driven immune responses (epmc).pdf DeepDyve Pubget Overpricing