Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/nature14514 http://scihub22266oqcxt.onion/10.1038/nature14514 C5583720!5583720 !26085274     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26085274 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26085274 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nature 2015 ; 522 (7556 ): 335-9 Nephropedia Template TP {{tp|p=26085274 |t=2015. Activating positive memory engrams suppresses depression-like behaviour |pdf=|usr=}}{{26085274 }} gab.com Text Activating positive memory engrams suppresses depression-like behaviour JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=26085274 #FOAvip Stress is considered a potent environmental risk factor for many behavioural abnormalities, including anxiety and mood disorders. Animal models can exhibit limited but quantifiable behavioural impairments resulting from chronic stress, including deficits in motivation, abnormal responses to behavioural challenges, and anhedonia. The hippocampus is thought to negatively regulate the stress response and to mediate various cognitive and mnemonic aspects of stress-induced impairments, although the neuronal underpinnings sufficient to support behavioural improvements are largely unknown. Here we acutely rescue stress-induced depression-related behaviours in mice by optogenetically reactivating dentate gyrus cells that were previously active during a positive experience. A brain-wide histological investigation, coupled with pharmacological and projection-specific optogenetic blockade experiments, identified glutamatergic activity in the hippocampus-amygdala-nucleus-accumbens pathway as a candidate circuit supporting the acute rescue. Finally, chronically reactivating hippocampal cells associated with a positive memory resulted in the rescue of stress-induced behavioural impairments and neurogenesis at time points beyond the light stimulation. Together, our data suggest that activating positive memories artificially is sufficient to suppress depression-like behaviours and point to dentate gyrus engram cells as potential therapeutic nodes for intervening with maladaptive behavioural states. Twit Text FOAVip Activating positive memory engrams suppresses depression-like behaviour ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=26085274 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26085274 #FOAvip English Wikipedia <ref>{{Cite pmid|26085274 }}</ref> Activating positive memory engrams suppresses depression-like behaviour #MMPMID26085274 Ramirez S ; Liu X ; MacDonald CJ ; Moffa A ; Zhou J ; Redondo RL ; Tonegawa S Nature 2015[Jun]; 522 (7556 ): 335-9 PMID26085274 show ga Stress is considered a potent environmental risk factor for many behavioural abnormalities, including anxiety and mood disorders. Animal models can exhibit limited but quantifiable behavioural impairments resulting from chronic stress, including deficits in motivation, abnormal responses to behavioural challenges, and anhedonia. The hippocampus is thought to negatively regulate the stress response and to mediate various cognitive and mnemonic aspects of stress-induced impairments, although the neuronal underpinnings sufficient to support behavioural improvements are largely unknown. Here we acutely rescue stress-induced depression-related behaviours in mice by optogenetically reactivating dentate gyrus cells that were previously active during a positive experience. A brain-wide histological investigation, coupled with pharmacological and projection-specific optogenetic blockade experiments, identified glutamatergic activity in the hippocampus-amygdala-nucleus-accumbens pathway as a candidate circuit supporting the acute rescue. Finally, chronically reactivating hippocampal cells associated with a positive memory resulted in the rescue of stress-induced behavioural impairments and neurogenesis at time points beyond the light stimulation. Together, our data suggest that activating positive memories artificially is sufficient to suppress depression-like behaviours and point to dentate gyrus engram cells as potential therapeutic nodes for intervening with maladaptive behavioural states. |Amygdala/cytology/metabolism/physiology [MESH] |Animals [MESH] |Behavior, Animal [MESH] |Depression/*psychology/*therapy [MESH] |Female [MESH] |Hippocampus/cytology/physiology [MESH] |Male [MESH] |Memory/*physiology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Neural Pathways [MESH] |Nucleus Accumbens/cytology/metabolism/physiology [MESH] |Optogenetics [MESH] |Pleasure/*physiology [MESH] |Proto-Oncogene Proteins c-fos/metabolism [MESH] |Stress, Psychological/psychology [MESH]Activating positive memory engrams suppresses depression-like behaviou(epmc).pdf DeepDyve Pubget Overpricing