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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Neurochem
2014 ; 129
(2
): 221-34
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Actin dynamics in growth cone motility and navigation
#MMPMID24164353
Gomez TM
; Letourneau PC
J Neurochem
2014[Apr]; 129
(2
): 221-34
PMID24164353
show ga
Motile growth cones lead growing axons through developing tissues to synaptic
targets. These behaviors depend on the organization and dynamics of actin
filaments that fill the growth cone leading margin [peripheral (P-) domain].
Actin filament organization in growth cones is regulated by actin-binding
proteins that control all aspects of filament assembly, turnover, interactions
with other filaments and cytoplasmic components, and participation in producing
mechanical forces. Actin filament polymerization drives protrusion of sensory
filopodia and lamellipodia, and actin filament connections to the plasma membrane
link the filament network to adhesive contacts of filopodia and lamellipodia with
other surfaces. These contacts stabilize protrusions and transduce mechanical
forces generated by actomyosin activity into traction that pulls an elongating
axon along the path toward its target. Adhesive ligands and extrinsic guidance
cues bind growth cone receptors and trigger signaling activities involving Rho
GTPases, kinases, phosphatases, cyclic nucleotides, and [Ca++] fluxes. These
signals regulate actin-binding proteins to locally modulate actin polymerization,
interactions, and force transduction to steer the growth cone leading margin
toward the sources of attractive cues and away from repellent guidance cues.
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