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10.1074/jbc.R115.655118 http://scihub22266oqcxt.onion/10.1074/jbc.R115.655118 C4661376!4661376 !26453304     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26453304 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2015 ; 290 (48 ): 28613-22 Nephropedia Template TP {{tp|p=26453304 |t=2015. Actin Out: Regulation of the Synaptic Cytoskeleton |pdf=|usr=}}{{26453304 }} gab.com Text Actin Out: Regulation of the Synaptic Cytoskeleton JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26453304 #FOAvip The small size of dendritic spines belies the elaborate role they play in excitatory synaptic transmission and ultimately complex behaviors. The cytoskeletal architecture of the spine is predominately composed of actin filaments. These filaments, which at first glance might appear simple, are also surprisingly complex. They dynamically assemble into different structures and serve as a platform for orchestrating the elaborate responses of the spine during spinogenesis and experience-dependent plasticity. Multiple mutations associated with human neurodevelopmental and psychiatric disorders involve genes that encode regulators of the synaptic cytoskeleton. A major, unresolved question is how the disruption of specific actin filament structures leads to the onset and progression of complex synaptic and behavioral phenotypes. This review will cover established and emerging mechanisms of actin cytoskeletal remodeling and how this influences specific aspects of spine biology that are implicated in disease. Twit Text FOAVip Actin Out: Regulation of the Synaptic Cytoskeleton ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=26453304 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26453304 #FOAvip English Wikipedia <ref>{{Cite pmid|26453304 }}</ref> Actin Out: Regulation of the Synaptic Cytoskeleton #MMPMID26453304 Spence EF ; Soderling SH J Biol Chem 2015[Nov]; 290 (48 ): 28613-22 PMID26453304 show ga The small size of dendritic spines belies the elaborate role they play in excitatory synaptic transmission and ultimately complex behaviors. The cytoskeletal architecture of the spine is predominately composed of actin filaments. These filaments, which at first glance might appear simple, are also surprisingly complex. They dynamically assemble into different structures and serve as a platform for orchestrating the elaborate responses of the spine during spinogenesis and experience-dependent plasticity. Multiple mutations associated with human neurodevelopmental and psychiatric disorders involve genes that encode regulators of the synaptic cytoskeleton. A major, unresolved question is how the disruption of specific actin filament structures leads to the onset and progression of complex synaptic and behavioral phenotypes. This review will cover established and emerging mechanisms of actin cytoskeletal remodeling and how this influences specific aspects of spine biology that are implicated in disease. |Actins/*metabolism [MESH] |Animals [MESH] |Humans [MESH] |Spinal Diseases/*metabolism/pathology [MESH] |Spine/*metabolism/pathology [MESH] |Stress Fibers/*metabolism/pathology [MESH]Actin Out: Regulation of the Synaptic Cytoskeleton (epmc).pdf DeepDyve Pubget Overpricing