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2016 ; 148
(ä): 1-6
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Acrolein metabolites, diabetes and insulin resistance
#MMPMID26991531
Feroe AG
; Attanasio R
; Scinicariello F
Environ Res
2016[Jul]; 148
(ä): 1-6
PMID26991531
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Acrolein is a dietary and environmental pollutant that has been associated in
vitro to dysregulate glucose transport. We investigated the association of
urinary acrolein metabolites N-acetyl-S-(3-hydroxypropyl)-l-cysteine (3-HPMA) and
N-acetyl-S-(carboxyethyl)-l-cysteine (CEMA) and their molar sum (?acrolein) with
diabetes using data from investigated 2027 adults who participated in the
2005-2006 National Health and Nutrition Examination Survey (NHANES). After
excluding participants taking insulin or other diabetes medication we, further,
investigated the association of the compounds with insulin resistance (n=850), as
a categorical outcome expressed by the homeostatic model assessment
(HOMA-IR>2.6). As secondary analyses, we investigated the association of the
compounds with HOMA-IR, HOMA-?, fasting insulin and fasting plasma glucose. The
analyses were performed using urinary creatinine as independent variable in the
models, and, as sensitivity analyses, the compounds were used as creatinine
corrected variables. Diabetes as well as insulin resistance (defined as
HOMA-IR>2.6) were positively associated with the 3-HPMA, CEMA and ?Acrolein with
evidence of a dose-response relationship (p<0.05). The highest 3rd and 4th
quartiles of CEMA compared to the lowest quartile were significantly associated
with higher HOMA-IR, HOMA-? and fasting insulin with a dose-response
relationship. The highest 3rd quartile of 3-HPMA and ?Acrolein were positively
and significantly associated with HOMA-IR, HOMA-? and fasting insulin. These
results suggest a need of further studies to fully understand the implications of
acrolein with type 2 diabetes and insulin.
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