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2018 ; 7
(1
): 33
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Acinetobacter: an emerging pathogen with a versatile secretome
#MMPMID29559620
Elhosseiny NM
; Attia AS
Emerg Microbes Infect
2018[Mar]; 7
(1
): 33
PMID29559620
show ga
Acinetobacter baumannii is a notorious pathogen that has emerged as a healthcare
nightmare in recent years because it causes serious infections that are
associated with high morbidity and mortality rates. Due to its exceptional
ability to acquire resistance to almost all available antibiotics, A. baumannii
is currently ranked as the first pathogen on the World Health Organization's
priority list for the development of new antibiotics. The versatile range of
effectors secreted by A. baumannii represents a large proportion of the virulence
arsenal identified in this bacterium to date. Thus, these factors, together with
the secretory machinery responsible for their extrusion into the extracellular
milieu, are key targets for novel therapeutics that are greatly needed to combat
this deadly pathogen. In this review, we provide a comprehensive, up-to-date
overview of the organization and regulatory aspects of the Acinetobacter
secretion systems, with a special emphasis on their versatile substrates that
could be targeted to fight the deadly infections caused by this elusive pathogen.