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10.4161/19336950.2014.958382 http://scihub22266oqcxt.onion/10.4161/19336950.2014.958382 C4594520!4594520 !25483283     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25483283 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Channels+(Austin) 2014 ; 8 (6 ): 481-7 Nephropedia Template TP {{tp|p=25483283 |t=2014. Acid-sensing ion channels: trafficking and pathophysiology |pdf=|usr=}}{{25483283 }} gab.com Text Acid-sensing ion channels: trafficking and pathophysiology JO: Channels (Austin) http://www.kidney.de/pget.php?&tw=1&pmid=25483283 #FOAvip Acid-sensing ion channels (ASICs) are proton-gated cation channels that are widely expressed in both the peripheral and central nervous systems. ASICs contribute to a variety of pathophysiological conditions that involve tissue acidosis, such as ischemic stroke, epileptic seizures and multiple sclerosis. Although much progress has been made in researching the structure-function relationship and pharmacology of ASICs, little is known about the trafficking of ASICs and its contribution to ASIC function. The recent identification of the mechanism of membrane insertion and endocytosis of ASIC1a highlights the emerging role of ASIC trafficking in regulating its pathophysiological functions. In this review, we summarize the recent advances and discuss future directions on this topic. Twit Text FOAVip Acid-sensing ion channels: trafficking and pathophysiology ????Channels (Austin) http://www.kidney.de/pget.php?&tw=1&pmid=25483283 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25483283 #FOAvip English Wikipedia <ref>{{Cite pmid|25483283 }}</ref> Acid-sensing ion channels: trafficking and pathophysiology #MMPMID25483283 Zeng WZ ; Liu DS ; Xu TL Channels (Austin) 2014[]; 8 (6 ): 481-7 PMID25483283 show ga Acid-sensing ion channels (ASICs) are proton-gated cation channels that are widely expressed in both the peripheral and central nervous systems. ASICs contribute to a variety of pathophysiological conditions that involve tissue acidosis, such as ischemic stroke, epileptic seizures and multiple sclerosis. Although much progress has been made in researching the structure-function relationship and pharmacology of ASICs, little is known about the trafficking of ASICs and its contribution to ASIC function. The recent identification of the mechanism of membrane insertion and endocytosis of ASIC1a highlights the emerging role of ASIC trafficking in regulating its pathophysiological functions. In this review, we summarize the recent advances and discuss future directions on this topic. |*Exocytosis [MESH] |Acid Sensing Ion Channels/chemistry/genetics/*metabolism [MESH] |Amino Acid Sequence [MESH] |Animals [MESH] |Humans [MESH] |Molecular Sequence Data [MESH] |Protein Binding [MESH] |Protein Sorting Signals [MESH]Acid-sensing ion channels: trafficking and pathophysiology (epmc).pdf DeepDyve Pubget Overpricing