Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.3389/fimmu.2015.00239 http://scihub22266oqcxt.onion/10.3389/fimmu.2015.00239 C4435041!4435041 !26042122     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26042122 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Front+Immunol 2015 ; 6 (?): 239 Nephropedia Template TP {{tp|p=26042122 |t=2015. Accelerated apoptosis of neutrophils in familial mediterranean Fever |pdf=|usr=}}{{26042122 }} gab.com Text Accelerated apoptosis of neutrophils in familial mediterranean Fever JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26042122 #FOAvip The causative mutations for familial Mediterranean fever (FMF) are located in the MEFV gene, which encodes pyrin. Pyrin modulates the susceptibility to apoptosis via its PYD domain, but how the mutated versions of pyrin affect apoptotic processes are poorly understood. Spontaneous and induced rates of systemic neutrophil apoptosis as well as the levels of proteins involved in apoptosis were investigated ex vivo in patients with FMF using flow cytometry and RT-qPCR. The freshly collected neutrophils from the patients in FMF remission displayed a significantly larger number of cells spontaneously entering apoptosis compared to control (6.27?±?2.14 vs. 1.69?±?0.18%). This elevated ratio was retained after 24?h incubation of neutrophils in the growth medium (32.4?±?7.41 vs. 7.65?±?1.32%). Correspondingly, the mRNA level for caspase-3 was also significantly increased under these conditions. In response to the inducing agents, the neutrophils from FMF patients also displayed significantly elevated apoptotic rates compared to control. The elevated rates, however, can be largely explained by the higher basal ratio of apoptotic cells in the former group. Monitoring of several proteins involved in apoptosis has not revealed any conventional mechanisms contributing to the enhanced apoptotic rate of neutrophils in FMF. Although the exact molecular mechanisms of accelerated neutrophil apoptosis in FMF remain unknown, it may provide a protection against excessive inflammation and tissue damage due to a massive infiltration of neutrophils in the acute period of the disease. Twit Text FOAVip Accelerated apoptosis of neutrophils in familial mediterranean Fever ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26042122 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26042122 #FOAvip English Wikipedia <ref>{{Cite pmid|26042122 }}</ref> Accelerated apoptosis of neutrophils in familial mediterranean Fever #MMPMID26042122 Manukyan G ; Aminov R ; Hakobyan G ; Davtyan T Front Immunol 2015[]; 6 (?): 239 PMID26042122 show ga The causative mutations for familial Mediterranean fever (FMF) are located in the MEFV gene, which encodes pyrin. Pyrin modulates the susceptibility to apoptosis via its PYD domain, but how the mutated versions of pyrin affect apoptotic processes are poorly understood. Spontaneous and induced rates of systemic neutrophil apoptosis as well as the levels of proteins involved in apoptosis were investigated ex vivo in patients with FMF using flow cytometry and RT-qPCR. The freshly collected neutrophils from the patients in FMF remission displayed a significantly larger number of cells spontaneously entering apoptosis compared to control (6.27?±?2.14 vs. 1.69?±?0.18%). This elevated ratio was retained after 24?h incubation of neutrophils in the growth medium (32.4?±?7.41 vs. 7.65?±?1.32%). Correspondingly, the mRNA level for caspase-3 was also significantly increased under these conditions. In response to the inducing agents, the neutrophils from FMF patients also displayed significantly elevated apoptotic rates compared to control. The elevated rates, however, can be largely explained by the higher basal ratio of apoptotic cells in the former group. Monitoring of several proteins involved in apoptosis has not revealed any conventional mechanisms contributing to the enhanced apoptotic rate of neutrophils in FMF. Although the exact molecular mechanisms of accelerated neutrophil apoptosis in FMF remain unknown, it may provide a protection against excessive inflammation and tissue damage due to a massive infiltration of neutrophils in the acute period of the disease. ?Accelerated apoptosis of neutrophils in familial mediterranean Fever (epmc).pdf DeepDyve Pubget Overpricing