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10.1371/journal.pone.0140189 http://scihub22266oqcxt.onion/10.1371/journal.pone.0140189 C4598111!4598111 !26448623     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26448623 &cmd=llinks): Failed to open stream: HTTP request failed! 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Accelerated Telomere Shortening in Acromegaly; IGF-I Induces Telomere Shortening and Cellular Senescence |pdf=|usr=}}{{26448623 }} gab.com Text Accelerated Telomere Shortening in Acromegaly; IGF-I Induces Telomere Shortening and Cellular Senescence JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26448623 #FOAvip OBJECTIVE: Patients with acromegaly exhibit reduced life expectancy and increased prevalence of age-related diseases, such as diabetes, hypertension, and cardiovascular disease. However, the underlying mechanism has not been fully elucidated. Telomere shortening is reportedly associated with reduced life expectancy and increased prevalence of these age-related diseases. METHODS: We measured telomere length in patients with acromegaly using quantitative PCR method. The effect of GH and IGF-I on telomere length and cellular senescence was examined in human skin fibroblasts. RESULTS: Patients with acromegaly exhibited shorter telomere length than age-, sex-, smoking-, and diabetes-matched control patients with non-functioning pituitary adenoma (0.62 ± 0.23 vs. 0.75 ± 0.35, respectively, P = 0.047). In addition, telomere length in acromegaly was negatively correlated with the disease duration (R2 = 0.210, P = 0.003). In vitro analysis revealed that not GH but IGF-I induced telomere shortening in human skin fibroblasts. Furthermore, IGF-I-treated cells showed increased senescence-associated ?-galactosidase activity and expression of p53 and p21 protein. IGF-I-treated cells reached the Hayflick limit earlier than GH- or vehicle-treated cells, indicating that IGF-I induces cellular senescence. CONCLUSION: Shortened telomeres in acromegaly and cellular senescence induced by IGF-I can explain, in part, the underlying mechanisms by which acromegaly exhibits an increased morbidity and mortality in association with the excess secretion of IGF-I. Twit Text FOAVip Accelerated Telomere Shortening in Acromegaly; IGF-I Induces Telomere Shortening and Cellular Senescence ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26448623 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26448623 #FOAvip English Wikipedia <ref>{{Cite pmid|26448623 }}</ref> Accelerated Telomere Shortening in Acromegaly; IGF-I Induces Telomere Shortening and Cellular Senescence #MMPMID26448623 Matsumoto R ; Fukuoka H ; Iguchi G ; Odake Y ; Yoshida K ; Bando H ; Suda K ; Nishizawa H ; Takahashi M ; Yamada S ; Ogawa W ; Takahashi Y PLoS One 2015[]; 10 (10 ): e0140189 PMID26448623 show ga OBJECTIVE: Patients with acromegaly exhibit reduced life expectancy and increased prevalence of age-related diseases, such as diabetes, hypertension, and cardiovascular disease. However, the underlying mechanism has not been fully elucidated. Telomere shortening is reportedly associated with reduced life expectancy and increased prevalence of these age-related diseases. METHODS: We measured telomere length in patients with acromegaly using quantitative PCR method. The effect of GH and IGF-I on telomere length and cellular senescence was examined in human skin fibroblasts. RESULTS: Patients with acromegaly exhibited shorter telomere length than age-, sex-, smoking-, and diabetes-matched control patients with non-functioning pituitary adenoma (0.62 ± 0.23 vs. 0.75 ± 0.35, respectively, P = 0.047). In addition, telomere length in acromegaly was negatively correlated with the disease duration (R2 = 0.210, P = 0.003). In vitro analysis revealed that not GH but IGF-I induced telomere shortening in human skin fibroblasts. Furthermore, IGF-I-treated cells showed increased senescence-associated ?-galactosidase activity and expression of p53 and p21 protein. IGF-I-treated cells reached the Hayflick limit earlier than GH- or vehicle-treated cells, indicating that IGF-I induces cellular senescence. CONCLUSION: Shortened telomeres in acromegaly and cellular senescence induced by IGF-I can explain, in part, the underlying mechanisms by which acromegaly exhibits an increased morbidity and mortality in association with the excess secretion of IGF-I. |*Telomere Shortening [MESH] |Acromegaly/*genetics/pathology [MESH] |Adult [MESH] |Aged [MESH] |Cells, Cultured [MESH] |Cellular Senescence [MESH] |Female [MESH] |Fibroblasts/physiology [MESH] |Human Growth Hormone/physiology [MESH] |Humans [MESH] |Insulin-Like Growth Factor I/*physiology [MESH] |Male [MESH] |Middle Aged [MESH]Accelerated Telomere Shortening in Acromegaly; IGF-I Induces Telomere (epmc).pdf DeepDyve Pubget Overpricing