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10.1016/j.bpj.2016.07.029 http://scihub22266oqcxt.onion/10.1016/j.bpj.2016.07.029 C5018129!5018129 !27602720     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27602720 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biophys+J 2016 ; 111 (5 ): 917-20 Nephropedia Template TP {{tp|p=27602720 |t=2016. Absolute Ligand Discrimination by Dimeric Signaling Receptors |pdf=|usr=}}{{27602720 }} gab.com Text Absolute Ligand Discrimination by Dimeric Signaling Receptors JO: Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=27602720 #FOAvip Many signaling pathways act through shared components, where different ligand molecules bind the same receptors or activate overlapping sets of response regulators downstream. Nevertheless, different ligands acting through cross-wired pathways often lead to different outcomes in terms of the target cell behavior and function. Although a number of mechanisms have been proposed, it still largely remains unclear how cells can reliably discriminate different molecular ligands under such circumstances. Here we show that signaling via ligand-induced receptor dimerization-a very common motif in cellular signaling-naturally incorporates a mechanism for the discrimination of ligands acting through the same receptor. Twit Text FOAVip Absolute Ligand Discrimination by Dimeric Signaling Receptors ????Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=27602720 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27602720 #FOAvip English Wikipedia <ref>{{Cite pmid|27602720 }}</ref> Absolute Ligand Discrimination by Dimeric Signaling Receptors #MMPMID27602720 Fathi S ; Nayak CR ; Feld JJ ; Zilman AG Biophys J 2016[Sep]; 111 (5 ): 917-20 PMID27602720 show ga Many signaling pathways act through shared components, where different ligand molecules bind the same receptors or activate overlapping sets of response regulators downstream. Nevertheless, different ligands acting through cross-wired pathways often lead to different outcomes in terms of the target cell behavior and function. Although a number of mechanisms have been proposed, it still largely remains unclear how cells can reliably discriminate different molecular ligands under such circumstances. Here we show that signaling via ligand-induced receptor dimerization-a very common motif in cellular signaling-naturally incorporates a mechanism for the discrimination of ligands acting through the same receptor. |*Ligands [MESH] |*Models, Molecular [MESH] |*Protein Binding [MESH] |*Protein Multimerization [MESH]Absolute Ligand Discrimination by Dimeric Signaling Receptors (epmc).pdf DeepDyve Pubget Overpricing