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2013 ; 2013
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Absence seizures in children
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Posner E
BMJ Clin Evid
2013[Dec]; 2013
(ä): ä PMID24351614
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INTRODUCTION: About 10% of seizures in children with epilepsy are typical absence
seizures. Absence seizures have a significant impact on quality of life. METHODS
AND OUTCOMES: We conducted a systematic review and aimed to answer the following
clinical question: What are the effects of treatments for typical absence
seizures in children? We searched: Medline, Embase, The Cochrane Library, and
other important databases up to July 2013 (Clinical Evidence reviews are updated
periodically; please check our website for the most up to date version of this
review). We included harms alerts from relevant organisations such as the US Food
and Drug Administration (FDA), the European Medicines Agency (EMA), and the UK
Medicines and Healthcare products Regulatory Agency (MHRA). RESULTS: We found 18
RCTs or systematic reviews of RCTs that met our inclusion criteria. We performed
a GRADE evaluation of the quality of evidence for interventions. CONCLUSIONS: In
this systematic review we present information relating to the effectiveness and
safety of the following interventions: clonazepam, ethosuximide, gabapentin,
lamotrigine, and valproate.