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2017 ; 8
(ä): 587
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English Wikipedia
Abscisic Acid as Pathogen Effector and Immune Regulator
#MMPMID28469630
Lievens L
; Pollier J
; Goossens A
; Beyaert R
; Staal J
Front Plant Sci
2017[]; 8
(ä): 587
PMID28469630
show ga
Abscisic acid (ABA) is a sesquiterpene signaling molecule produced in all
kingdoms of life. To date, the best known functions of ABA are derived from its
role as a major phytohormone in plant abiotic stress resistance. Different
organisms have developed different biosynthesis and signal transduction pathways
related to ABA. Despite this, there are also intriguing common themes where ABA
often suppresses host immune responses and is utilized by pathogens as an
effector molecule. ABA also seems to play an important role in compatible
mutualistic interactions such as mycorrhiza and rhizosphere bacteria with plants,
and possibly also the animal gut microbiome. The frequent use of ABA in
inter-species communication could be a possible reason for the wide distribution
and re-invention of ABA as a signaling molecule in different organisms. In humans
and animal models, it has been shown that ABA treatment or nutrient-derived ABA
is beneficial in inflammatory diseases like colitis and type 2 diabetes, which
confer potential to ABA as an interesting nutraceutical or pharmacognostic drug.
The anti-inflammatory activity, cellular metabolic reprogramming, and other
beneficial physiological and psychological effects of ABA treatment in humans and
animal models has sparked an interest in this molecule and its signaling pathway
as a novel pharmacological target. In contrast to plants, however, very little is
known about the ABA biosynthesis and signaling in other organisms. Genes, tools
and knowledge about ABA from plant sciences and studies of phytopathogenic fungi
might benefit biomedical studies on the physiological role of endogenously
generated ABA in humans.