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2016 ; 22
(33
): 7486-99
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Aberrant regulation of Wnt signaling in hepatocellular carcinoma
#MMPMID27672271
Liu LJ
; Xie SX
; Chen YT
; Xue JL
; Zhang CJ
; Zhu F
World J Gastroenterol
2016[Sep]; 22
(33
): 7486-99
PMID27672271
show ga
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies in the
world. Several signaling pathways, including the wingless/int-1 (Wnt) signaling
pathway, have been shown to be commonly activated in HCC. The Wnt signaling
pathway can be triggered via both catenin ?1 (CTNNB1)-dependent (also known as
"canonical") and CTNNB1-independent (often referred to as "non-canonical")
pathways. Specifically, the canonical Wnt pathway is one of those most frequently
reported in HCC. Aberrant regulation from three complexes (the cell-surface
receptor complex, the cytoplasmic destruction complex and the nuclear
CTNNB1/T-cell-specific transcription factor/lymphoid enhancer binding factor
transcriptional complex) are all involved in HCC. Although the non-canonical Wnt
pathway is rarely reported, two main non-canonical pathways, Wnt/planar cell
polarity pathway and Wnt/Ca(2+) pathway, participate in the regulation of
hepatocarcinogenesis. Interestingly, the canonical Wnt pathway is antagonized by
non-canonical Wnt signaling in HCC. Moreover, other signaling cascades have also
been demonstrated to regulate the Wnt pathway through crosstalk in HCC
pathogenesis. This review provides a perspective on the emerging evidence that
the aberrant regulation of Wnt signaling is a critical mechanism for the
development of HCC. Furthermore, crosstalk between different signaling pathways
might be conducive to the development of novel molecular targets of HCC.
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