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2017 ; 8
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AUF1 regulation of coding and noncoding RNA
#MMPMID27620010
White EJ
; Matsangos AE
; Wilson GM
Wiley Interdiscip Rev RNA
2017[Mar]; 8
(2
): ä PMID27620010
show ga
AUF1 is a family of four RNA-binding proteins (RBPs) generated by alternative
pre-messenger RNA (pre-mRNA) splicing, with canonical roles in controlling the
stability and/or translation of mRNA targets based on recognition of AU-rich
sequences within mRNA 3' untranslated regions. However, recent studies
identifying AUF1 target sites across the transcriptome have revealed that these
canonical functions are but a subset of its roles in posttranscriptional
regulation of gene expression. In this review, we describe recent developments in
our understanding of the RNA-binding properties of AUF1 together with their
biochemical implications and roles in directing mRNA decay and translation. This
is then followed by a survey of newly discovered activities for AUF1 proteins in
control of miRNA synthesis and function, including miRNA assembly into microRNA
(miRNA)-loaded RNA-induced silencing complexes (miRISCs), miRISC targeting to
mRNA substrates, interplay with an expanding network of other cellular RBPs, and
reciprocal regulatory relationships between miRNA and AUF1 synthesis. Finally, we
discuss recently reported relationships between AUF1 and long noncoding RNAs and
regulatory roles on viral RNA substrates. Cumulatively, these findings have
significantly expanded our appreciation of the scope and diversity of AUF1
functions in the cell, and are prompting an exciting array of new questions
moving forward. WIREs RNA 2017, 8:e1393. doi: 10.1002/wrna.1393 For further
resources related to this article, please visit the WIREs website.
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