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10.1002/anie.202517843 http://scihub22266oqcxt.onion/10.1002/anie.202517843 41108578!ä!41108578 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=41108578&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\41108578.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Angew+Chem+Int+Ed+Engl 2025 ; ä (ä): e202517843 Nephropedia Template TP {{tp|p=41108578|t=2025. ATP-Powered Signaling Between Artificial and Living Cells |pdf=|usr=}}{{41108578}} gab.com Text ATP-Powered Signaling Between Artificial and Living Cells JO: Angew Chem Int Ed Engl http://www.kidney.de/pget.php?&tw=1&pmid=41108578 #FOAvip ATP is the energy currency of life and is overabundant in the tumor microenvironment, where it has been suggested as a target for cancer therapy. We introduce ATP-dissipative delivery of DNA signals from artificial cells to living cells by exploiting an ATP-driven reaction network that transiently ejects DNA Signal strands from the shielded artificial cell interior to the extracellular medium of living cells. We customize the Signal for intracellular uptake or for extracellular instruction using a cytokine-ssDNA chimera that can trigger efficient intracellular downstream signaling programs. Our study discusses details of system design on a timer circuit and artificial cell level, system integration challenges, and how ATP concentrations regulate the transient delivery. The strategy can be extended to deliver therapeutic oligonucleotides for applications in gene therapy and gene silencing. For cancer therapy, it can use naturally enhanced ATP levels to induce selective delivery of therapeutic oligonucleotides. Twit Text FOAVip ATP-Powered Signaling Between Artificial and Living Cells ????Angew Chem Int Ed Engl http://www.kidney.de/pget.php?&tw=1&pmid=41108578 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41108578 #FOAvip English Wikipedia <ref>{{Cite pmid|41108578}}</ref> ATP-Powered Signaling Between Artificial and Living Cells #MMPMID41108578 Sethi S; Sharma C; Walther A Angew Chem Int Ed Engl 2025[Oct]; ä (ä): e202517843 PMID41108578show ga ATP is the energy currency of life and is overabundant in the tumor microenvironment, where it has been suggested as a target for cancer therapy. We introduce ATP-dissipative delivery of DNA signals from artificial cells to living cells by exploiting an ATP-driven reaction network that transiently ejects DNA Signal strands from the shielded artificial cell interior to the extracellular medium of living cells. We customize the Signal for intracellular uptake or for extracellular instruction using a cytokine-ssDNA chimera that can trigger efficient intracellular downstream signaling programs. Our study discusses details of system design on a timer circuit and artificial cell level, system integration challenges, and how ATP concentrations regulate the transient delivery. The strategy can be extended to deliver therapeutic oligonucleotides for applications in gene therapy and gene silencing. For cancer therapy, it can use naturally enhanced ATP levels to induce selective delivery of therapeutic oligonucleotides. äATP-Powered Signaling Between Artificial and Living Cells (epmc).pdf DeepDyve Pubget Overpricing