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10.1038/srep28789 http://scihub22266oqcxt.onion/10.1038/srep28789 C4926121!4926121 !27352931     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27352931 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27352931 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 28789 Nephropedia Template TP {{tp|p=27352931 |t=2016. ASXL1 plays an important role in erythropoiesis |pdf=|usr=}}{{27352931 }} gab.com Text ASXL1 plays an important role in erythropoiesis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27352931 #FOAvip ASXL1 mutations are found in a spectrum of myeloid malignancies with poor prognosis. Recently, we reported that Asxl1(+/-) mice develop myelodysplastic syndrome (MDS) or MDS and myeloproliferative neoplasms (MPN) overlapping diseases (MDS/MPN). Although defective erythroid maturation and anemia are associated with the prognosis of patients with MDS or MDS/MPN, the role of ASXL1 in erythropoiesis remains unclear. Here, we showed that chronic myelomonocytic leukemia (CMML) patients with ASXL1 mutations exhibited more severe anemia with a significantly increased proportion of bone marrow (BM) early stage erythroblasts and reduced enucleated erythrocytes compared to CMML patients with WT ASXL1. Knockdown of ASXL1 in cord blood CD34(+) cells reduced erythropoiesis and impaired erythrocyte enucleation. Consistently, the BM and spleens of VavCre(+);Asxl1(f/f) (Asxl1(?/?)) mice had less numbers of erythroid progenitors than Asxl1(f/f) controls. Asxl1(?/?) mice also had an increased percentage of erythroblasts and a reduced erythrocyte enucleation in their BM compared to littermate controls. Furthermore, Asxl1(?/?) erythroblasts revealed altered expression of genes involved in erythroid development and homeostasis, which was associated with lower levels of H3K27me3 and H3K4me3. Our study unveils a key role for ASXL1 in erythropoiesis and indicates that ASXL1 loss hinders erythroid development/maturation, which could be of prognostic value for MDS/MPN patients. Twit Text FOAVip ASXL1 plays an important role in erythropoiesis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27352931 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27352931 #FOAvip English Wikipedia <ref>{{Cite pmid|27352931 }}</ref> ASXL1 plays an important role in erythropoiesis #MMPMID27352931 Shi H ; Yamamoto S ; Sheng M ; Bai J ; Zhang P ; Chen R ; Chen S ; Shi L ; Abdel-Wahab O ; Xu M ; Zhou Y ; Yang FC Sci Rep 2016[Jun]; 6 (ä): 28789 PMID27352931 show ga ASXL1 mutations are found in a spectrum of myeloid malignancies with poor prognosis. Recently, we reported that Asxl1(+/-) mice develop myelodysplastic syndrome (MDS) or MDS and myeloproliferative neoplasms (MPN) overlapping diseases (MDS/MPN). Although defective erythroid maturation and anemia are associated with the prognosis of patients with MDS or MDS/MPN, the role of ASXL1 in erythropoiesis remains unclear. Here, we showed that chronic myelomonocytic leukemia (CMML) patients with ASXL1 mutations exhibited more severe anemia with a significantly increased proportion of bone marrow (BM) early stage erythroblasts and reduced enucleated erythrocytes compared to CMML patients with WT ASXL1. Knockdown of ASXL1 in cord blood CD34(+) cells reduced erythropoiesis and impaired erythrocyte enucleation. Consistently, the BM and spleens of VavCre(+);Asxl1(f/f) (Asxl1(?/?)) mice had less numbers of erythroid progenitors than Asxl1(f/f) controls. Asxl1(?/?) mice also had an increased percentage of erythroblasts and a reduced erythrocyte enucleation in their BM compared to littermate controls. Furthermore, Asxl1(?/?) erythroblasts revealed altered expression of genes involved in erythroid development and homeostasis, which was associated with lower levels of H3K27me3 and H3K4me3. Our study unveils a key role for ASXL1 in erythropoiesis and indicates that ASXL1 loss hinders erythroid development/maturation, which could be of prognostic value for MDS/MPN patients. |*Erythropoiesis [MESH] |Animals [MESH] |Apoptosis [MESH] |Cell Differentiation [MESH] |Epigenesis, Genetic [MESH] |Erythroid Precursor Cells/*physiology [MESH] |Histones/metabolism [MESH] |Humans [MESH] |Mice, Inbred C57BL [MESH] |Mice, Transgenic [MESH]ASXL1 plays an important role in erythropoiesis (epmc).pdf DeepDyve Pubget Overpricing