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10.1042/BST20160191 http://scihub22266oqcxt.onion/10.1042/BST20160191 C5844352!5844352 !28620038     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28620038 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biochem+Soc+Trans 2017 ; 45 (3 ): 771-779 Nephropedia Template TP {{tp|p=28620038 |t=2017. APPL1 is a multifunctional endosomal signaling adaptor protein |pdf=|usr=}}{{28620038 }} gab.com Text APPL1 is a multifunctional endosomal signaling adaptor protein JO: Biochem Soc Trans http://www.kidney.de/pget.php?&tw=1&pmid=28620038 #FOAvip Endosomal adaptor proteins are important regulators of signaling pathways underlying many biological processes. These adaptors can integrate signals from multiple pathways via localization to specific endosomal compartments, as well as through multiple protein-protein interactions. One such adaptor protein that has been implicated in regulating signaling pathways is the adaptor protein containing a pleckstrin homology (PH) domain, phosphotyrosine-binding (PTB) domain, and leucine zipper motif 1 (APPL1). APPL1 localizes to a subset of Rab5-positive endosomes through its Bin-Amphiphysin-Rvs and PH domains, and it coordinates signaling pathways through its interaction with many signaling receptors and proteins through its PTB domain. This review discusses our current understanding of the role of APPL1 in signaling and trafficking, as well as highlights recent work into the function of APPL1 in cell migration and adhesion. Twit Text FOAVip APPL1 is a multifunctional endosomal signaling adaptor protein ????Biochem Soc Trans http://www.kidney.de/pget.php?&tw=1&pmid=28620038 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28620038 #FOAvip English Wikipedia <ref>{{Cite pmid|28620038 }}</ref> APPL1 is a multifunctional endosomal signaling adaptor protein #MMPMID28620038 Diggins NL ; Webb DJ Biochem Soc Trans 2017[Jun]; 45 (3 ): 771-779 PMID28620038 show ga Endosomal adaptor proteins are important regulators of signaling pathways underlying many biological processes. These adaptors can integrate signals from multiple pathways via localization to specific endosomal compartments, as well as through multiple protein-protein interactions. One such adaptor protein that has been implicated in regulating signaling pathways is the adaptor protein containing a pleckstrin homology (PH) domain, phosphotyrosine-binding (PTB) domain, and leucine zipper motif 1 (APPL1). APPL1 localizes to a subset of Rab5-positive endosomes through its Bin-Amphiphysin-Rvs and PH domains, and it coordinates signaling pathways through its interaction with many signaling receptors and proteins through its PTB domain. This review discusses our current understanding of the role of APPL1 in signaling and trafficking, as well as highlights recent work into the function of APPL1 in cell migration and adhesion. |*Signal Transduction [MESH] |Adaptor Proteins, Signal Transducing/*metabolism/physiology [MESH] |Animals [MESH] |Endosomes/metabolism [MESH] |Humans [MESH]APPL1 is a multifunctional endosomal signaling adaptor protein (epmc).pdf DeepDyve Pubget Overpricing