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10.3389/fnmol.2017.00063 http://scihub22266oqcxt.onion/10.3389/fnmol.2017.00063 C5344993!5344993 !28344547     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28344547 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Front+Mol+Neurosci 2017 ; 10 (ä): 63 Nephropedia Template TP {{tp|p=28344547 |t=2017. APP Function and Lipids: A Bidirectional Link |pdf=|usr=}}{{28344547 }} gab.com Text APP Function and Lipids: A Bidirectional Link JO: Front Mol Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=28344547 #FOAvip Extracellular neuritic plaques, composed of aggregated amyloid-? (A?) peptides, are one of the major histopathological hallmarks of Alzheimer's disease (AD), a progressive, irreversible neurodegenerative disorder and the most common cause of dementia in the elderly. One of the most prominent risk factor for sporadic AD, carrying one or two aberrant copies of the apolipoprotein E (ApoE) ?4 alleles, closely links AD to lipids. Further, several lipid classes and fatty acids have been reported to be changed in the brain of AD-affected individuals. Interestingly, the observed lipid changes in the brain seem not only to be a consequence of the disease but also modulate A? generation. In line with these observations, protective lipids being able to decrease A? generation and also potential negative lipids in respect to AD were identified. Mechanistically, A? peptides are generated by sequential proteolytic processing of the amyloid precursor protein (APP) by ?- and ?-secretase. The ?-secretase appears to compete with ?-secretase for the initial cleavage of APP, preventing A? production. All APP-cleaving secretases as well as APP are transmembrane proteins, further illustrating the impact of lipids on A? generation. Beside the pathological impact of A?, accumulating evidence suggests that A? and the APP intracellular domain (AICD) play an important role in regulating lipid homeostasis, either by direct effects or by affecting gene expression or protein stability of enzymes involved in the de novo synthesis of different lipid classes. This review summarizes the current literature addressing the complex bidirectional link between lipids and AD and APP processing including lipid alterations found in AD post mortem brains, lipids that alter APP processing and the physiological functions of A? and AICD in the regulation of several lipid metabolism pathways. Twit Text FOAVip APP Function and Lipids: A Bidirectional Link ????Front Mol Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=28344547 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28344547 #FOAvip English Wikipedia <ref>{{Cite pmid|28344547 }}</ref> APP Function and Lipids: A Bidirectional Link #MMPMID28344547 Grimm MO ; Mett J ; Grimm HS ; Hartmann T Front Mol Neurosci 2017[]; 10 (ä): 63 PMID28344547 show ga Extracellular neuritic plaques, composed of aggregated amyloid-? (A?) peptides, are one of the major histopathological hallmarks of Alzheimer's disease (AD), a progressive, irreversible neurodegenerative disorder and the most common cause of dementia in the elderly. One of the most prominent risk factor for sporadic AD, carrying one or two aberrant copies of the apolipoprotein E (ApoE) ?4 alleles, closely links AD to lipids. Further, several lipid classes and fatty acids have been reported to be changed in the brain of AD-affected individuals. Interestingly, the observed lipid changes in the brain seem not only to be a consequence of the disease but also modulate A? generation. In line with these observations, protective lipids being able to decrease A? generation and also potential negative lipids in respect to AD were identified. Mechanistically, A? peptides are generated by sequential proteolytic processing of the amyloid precursor protein (APP) by ?- and ?-secretase. The ?-secretase appears to compete with ?-secretase for the initial cleavage of APP, preventing A? production. All APP-cleaving secretases as well as APP are transmembrane proteins, further illustrating the impact of lipids on A? generation. Beside the pathological impact of A?, accumulating evidence suggests that A? and the APP intracellular domain (AICD) play an important role in regulating lipid homeostasis, either by direct effects or by affecting gene expression or protein stability of enzymes involved in the de novo synthesis of different lipid classes. This review summarizes the current literature addressing the complex bidirectional link between lipids and AD and APP processing including lipid alterations found in AD post mortem brains, lipids that alter APP processing and the physiological functions of A? and AICD in the regulation of several lipid metabolism pathways. äAPP Function and Lipids: A Bidirectional Link (epmc).pdf DeepDyve Pubget Overpricing