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2015 ; 195
(10
): 4565-70
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APOBEC3 Proteins in Viral Immunity
#MMPMID26546688
Stavrou S
; Ross SR
J Immunol
2015[Nov]; 195
(10
): 4565-70
PMID26546688
show ga
Apolipoprotein B editing complex 3 family members are cytidine deaminases that
play important roles in intrinsic responses to infection by retroviruses and have
been implicated in the control of other viruses, such as parvoviruses,
herpesviruses, papillomaviruses, hepatitis B virus, and retrotransposons.
Although their direct effect on modification of viral DNA has been clearly
demonstrated, whether they play additional roles in innate and adaptive immunity
to viruses is less clear. We review the data regarding the various steps in the
innate and adaptive immune response to virus infection in which apolipoprotein B
editing complex 3 proteins have been implicated.
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