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10.1016/j.cmet.2014.03.002 http://scihub22266oqcxt.onion/10.1016/j.cmet.2014.03.002 C4287273!4287273 !24726383     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24726383 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Cell+Metab 2014 ; 20 (1 ): 10-25 Nephropedia Template TP {{tp|p=24726383 |t=2014. AMPK at the nexus of energetics and aging |pdf=|usr=}}{{24726383 }} gab.com Text AMPK at the nexus of energetics and aging JO: Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=24726383 #FOAvip When energy supply is low, organisms respond by slowing aging and increasing resistance to diverse age-related pathologies. Targeting the mechanisms underpinning this response may therefore treat multiple disorders through a single intervention. Here, we discuss AMP-activated protein kinase (AMPK) as an integrator and mediator of several pathways and processes linking energetics to longevity. Activated by low energy, AMPK is both prolongevity and druggable, but its role in some pathologies may not be beneficial. As such, activating AMPK may modulate multiple longevity pathways to promote healthy aging, but unlocking its full potential may require selective targeting toward substrates involved in longevity assurance. Twit Text FOAVip AMPK at the nexus of energetics and aging ????Cell Metab http://www.kidney.de/pget.php?&tw=1&pmid=24726383 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24726383 #FOAvip English Wikipedia <ref>{{Cite pmid|24726383 }}</ref> AMPK at the nexus of energetics and aging #MMPMID24726383 Burkewitz K ; Zhang Y ; Mair WB Cell Metab 2014[Jul]; 20 (1 ): 10-25 PMID24726383 show ga When energy supply is low, organisms respond by slowing aging and increasing resistance to diverse age-related pathologies. Targeting the mechanisms underpinning this response may therefore treat multiple disorders through a single intervention. Here, we discuss AMP-activated protein kinase (AMPK) as an integrator and mediator of several pathways and processes linking energetics to longevity. Activated by low energy, AMPK is both prolongevity and druggable, but its role in some pathologies may not be beneficial. As such, activating AMPK may modulate multiple longevity pathways to promote healthy aging, but unlocking its full potential may require selective targeting toward substrates involved in longevity assurance. |*Aging [MESH] |*Energy Metabolism/drug effects [MESH] |AMP-Activated Protein Kinases/chemistry/*metabolism [MESH] |Animals [MESH] |Aspirin/pharmacology [MESH] |Humans [MESH] |Metabolic Diseases/metabolism/pathology [MESH] |Metformin/pharmacology [MESH] |Mitochondria/metabolism [MESH] |Neoplasms/metabolism/pathology [MESH] |Resveratrol [MESH]AMPK at the nexus of energetics and aging (epmc).pdf DeepDyve Pubget Overpricing