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10.1038/emm.2016.16 http://scihub22266oqcxt.onion/10.1038/emm.2016.16 C4855276!4855276 !27034026     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27034026 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Exp+Mol+Med 2016 ; 48 (4 ): e224 Nephropedia Template TP {{tp|p=27034026 |t=2016. AMPK activators: mechanisms of action and physiological activities |pdf=|usr=}}{{27034026 }} gab.com Text AMPK activators: mechanisms of action and physiological activities JO: Exp Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=27034026 #FOAvip AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis, which coordinates metabolic pathways and thus balances nutrient supply with energy demand. Because of the favorable physiological outcomes of AMPK activation on metabolism, AMPK has been considered to be an important therapeutic target for controlling human diseases including metabolic syndrome and cancer. Thus, activators of AMPK may have potential as novel therapeutics for these diseases. In this review, we provide a comprehensive summary of both indirect and direct AMPK activators and their modes of action in relation to the structure of AMPK. We discuss the functional differences among isoform-specific AMPK complexes and their significance regarding the development of novel AMPK activators and the potential for combining different AMPK activators in the treatment of human disease. Twit Text FOAVip AMPK activators: mechanisms of action and physiological activities ????Exp Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=27034026 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27034026 #FOAvip English Wikipedia <ref>{{Cite pmid|27034026 }}</ref> AMPK activators: mechanisms of action and physiological activities #MMPMID27034026 Kim J ; Yang G ; Kim Y ; Kim J ; Ha J Exp Mol Med 2016[Apr]; 48 (4 ): e224 PMID27034026 show ga AMP-activated protein kinase (AMPK) is a central regulator of energy homeostasis, which coordinates metabolic pathways and thus balances nutrient supply with energy demand. Because of the favorable physiological outcomes of AMPK activation on metabolism, AMPK has been considered to be an important therapeutic target for controlling human diseases including metabolic syndrome and cancer. Thus, activators of AMPK may have potential as novel therapeutics for these diseases. In this review, we provide a comprehensive summary of both indirect and direct AMPK activators and their modes of action in relation to the structure of AMPK. We discuss the functional differences among isoform-specific AMPK complexes and their significance regarding the development of novel AMPK activators and the potential for combining different AMPK activators in the treatment of human disease. |AMP-Activated Protein Kinases/chemistry/*metabolism [MESH] |Allosteric Regulation [MESH] |Animals [MESH] |Enzyme Activation/drug effects [MESH] |Humans [MESH]AMPK activators: mechanisms of action and physiological activities (epmc).pdf DeepDyve Pubget Overpricing