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10.1007/s10495-015-1176-3 http://scihub22266oqcxt.onion/10.1007/s10495-015-1176-3 C4602066!4602066 !26423274     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26423274 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26423274 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Apoptosis 2015 ; 20 (12 ): 1577-86 Nephropedia Template TP {{tp|p=26423274 |t=2015. AMBRA1 and SQSTM1 expression pattern in prostate cancer |pdf=|usr=}}{{26423274 }} gab.com Text AMBRA1 and SQSTM1 expression pattern in prostate cancer JO: Apoptosis http://www.kidney.de/pget.php?&tw=1&pmid=26423274 #FOAvip Prostate cancer is among the most commonly diagnosed male diseases and a leading cause of cancer mortality in men. There is emerging evidence that autophagy plays an important role in malignant cell survival and offers protection from the anti-cancer drugs in prostate cancer cells. AMBRA1 and the autophagic protein sequestosome-1 (SQSTM1; p62) expression were evaluated by immunohistochemistry and western blot on tissue samples from both benign and malignant prostatic lesions. The data reported in this pilot study demonstrated an increased expression of AMBRA1 and SQSTM1, which were also associated with an accumulation of LC3II in prostate cancer but not in benign lesion. In the present study we found that: (i) at variance with benign lesion, prostate cancer cells underwent SQSTM1 accumulation, i.e., clearly displayed a defective autophagic process but, also, (ii) prostate cancer accumulated AMBRA1 and (iii) this increase positively correlated with the Gleason score. These results underscore a possible implication of autophagy in prostate cancer phenotype and of AMBRA1 as possible cancer progression biomarker in this malignancy. Twit Text FOAVip AMBRA1 and SQSTM1 expression pattern in prostate cancer ????Apoptosis http://www.kidney.de/pget.php?&tw=1&pmid=26423274 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26423274 #FOAvip English Wikipedia <ref>{{Cite pmid|26423274 }}</ref> AMBRA1 and SQSTM1 expression pattern in prostate cancer #MMPMID26423274 Falasca L ; Torino F ; Marconi M ; Costantini M ; Pompeo V ; Sentinelli S ; De Salvo L ; Patrizio M ; Padula C ; Gallucci M ; Piacentini M ; Malorni W Apoptosis 2015[Dec]; 20 (12 ): 1577-86 PMID26423274 show ga Prostate cancer is among the most commonly diagnosed male diseases and a leading cause of cancer mortality in men. There is emerging evidence that autophagy plays an important role in malignant cell survival and offers protection from the anti-cancer drugs in prostate cancer cells. AMBRA1 and the autophagic protein sequestosome-1 (SQSTM1; p62) expression were evaluated by immunohistochemistry and western blot on tissue samples from both benign and malignant prostatic lesions. The data reported in this pilot study demonstrated an increased expression of AMBRA1 and SQSTM1, which were also associated with an accumulation of LC3II in prostate cancer but not in benign lesion. In the present study we found that: (i) at variance with benign lesion, prostate cancer cells underwent SQSTM1 accumulation, i.e., clearly displayed a defective autophagic process but, also, (ii) prostate cancer accumulated AMBRA1 and (iii) this increase positively correlated with the Gleason score. These results underscore a possible implication of autophagy in prostate cancer phenotype and of AMBRA1 as possible cancer progression biomarker in this malignancy. |Adaptor Proteins, Signal Transducing/*metabolism [MESH] |Aged [MESH] |Antineoplastic Agents/therapeutic use [MESH] |Autophagy/physiology [MESH] |Biomarkers, Tumor/metabolism [MESH] |Cell Survival/physiology [MESH] |Humans [MESH] |Male [MESH] |Middle Aged [MESH] |Pilot Projects [MESH] |Prostate/metabolism [MESH] |Prostatic Neoplasms/drug therapy/*metabolism [MESH] |Retrospective Studies [MESH]AMBRA1 and SQSTM1 expression pattern in prostate cancer (epmc).pdf DeepDyve Pubget Overpricing