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10.1016/j.tips.2014.09.005 http://scihub22266oqcxt.onion/10.1016/j.tips.2014.09.005 C4254113!4254113 !25294000     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25294000 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Trends+Pharmacol+Sci 2014 ; 35 (11 ): 575-82 Nephropedia Template TP {{tp|p=25294000 |t=2014. AGXT2: a promiscuous aminotransferase |pdf=|usr=}}{{25294000 }} gab.com Text AGXT2: a promiscuous aminotransferase JO: Trends Pharmacol Sci http://www.kidney.de/pget.php?&tw=1&pmid=25294000 #FOAvip Alanine-glyoxylate aminotransferase 2 (AGXT2) is a multifunctional mitochondrial aminotransferase that was first identified in 1978. The physiological importance of AGXT2 was largely overlooked for three decades because AGXT2 is less active in glyoxylate metabolism than AGXT1, the enzyme that is deficient in primary hyperoxaluria type I. Recently, several novel functions of AGXT2 have been 'rediscovered' in the setting of modern genomic and metabolomic studies. It is now apparent that AGXT2 has multiple substrates and products and that altered AGXT2 activity may contribute to the pathogenesis of cardiovascular, renal, neurological, and hematological diseases. This article reviews the biochemical properties and physiological functions of AGXT2, its unique role at the intersection of key mitochondrial pathways, and its potential as a drug target. Twit Text FOAVip AGXT2: a promiscuous aminotransferase ????Trends Pharmacol Sci http://www.kidney.de/pget.php?&tw=1&pmid=25294000 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25294000 #FOAvip English Wikipedia <ref>{{Cite pmid|25294000 }}</ref> AGXT2: a promiscuous aminotransferase #MMPMID25294000 Rodionov RN ; Jarzebska N ; Weiss N ; Lentz SR Trends Pharmacol Sci 2014[Nov]; 35 (11 ): 575-82 PMID25294000 show ga Alanine-glyoxylate aminotransferase 2 (AGXT2) is a multifunctional mitochondrial aminotransferase that was first identified in 1978. The physiological importance of AGXT2 was largely overlooked for three decades because AGXT2 is less active in glyoxylate metabolism than AGXT1, the enzyme that is deficient in primary hyperoxaluria type I. Recently, several novel functions of AGXT2 have been 'rediscovered' in the setting of modern genomic and metabolomic studies. It is now apparent that AGXT2 has multiple substrates and products and that altered AGXT2 activity may contribute to the pathogenesis of cardiovascular, renal, neurological, and hematological diseases. This article reviews the biochemical properties and physiological functions of AGXT2, its unique role at the intersection of key mitochondrial pathways, and its potential as a drug target. |Animals [MESH] |Humans [MESH]AGXT2: a promiscuous aminotransferase (epmc).pdf DeepDyve Pubget Overpricing