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2016 ; 78
(ä): 243-76
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ADAM Proteases and Gastrointestinal Function
#MMPMID26667078
Jones JC
; Rustagi S
; Dempsey PJ
Annu Rev Physiol
2016[]; 78
(ä): 243-76
PMID26667078
show ga
A disintegrin and metalloproteinases (ADAMs) are a family of cell surface
proteases that regulate diverse cellular functions, including cell adhesion,
migration, cellular signaling, and proteolysis. Proteolytically active ADAMs are
responsible for ectodomain shedding of membrane-associated proteins. ADAMs
rapidly modulate key cell signaling pathways in response to changes in the
extracellular environment (e.g., inflammation) and play a central role in
coordinating intercellular communication within the local microenvironment.
ADAM10 and ADAM17 are the most studied members of the ADAM family in the
gastrointestinal tract. ADAMs regulate many cellular processes associated with
intestinal development, cell fate specification, and the maintenance of
intestinal stem cell/progenitor populations. Several signaling pathway molecules
that undergo ectodomain shedding by ADAMs [e.g., ligands and receptors from
epidermal growth factor receptor (EGFR)/ErbB and tumor necrosis factor ? (TNF?)
receptor (TNFR) families] help drive and control intestinal inflammation and
injury/repair responses. Dysregulation of these processes through aberrant ADAM
expression or sustained ADAM activity is linked to chronic inflammation,
inflammation-associated cancer, and tumorigenesis.
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