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10.5041/RMMJ.10255 http://scihub22266oqcxt.onion/10.5041/RMMJ.10255 C5101002!5101002 !27824549     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27824549 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27824549 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Rambam+Maimonides+Med+J 2016 ; 7 (4 ): ä Nephropedia Template TP {{tp|p=27824549 |t=2016. ACPAs Are Much More Than Diagnostic Autoantibodies |pdf=|usr=}}{{27824549 }} gab.com Text ACPAs Are Much More Than Diagnostic Autoantibodies JO: Rambam Maimonides Med J http://www.kidney.de/pget.php?&tw=1&pmid=27824549 #FOAvip Anti-citrullinated protein autoantibodies (ACPAs) are the major autoantibodies in rheumatoid arthritis (RA). Anti-citrullinated protein autoantibodies are directed against different citrullinated antigens, including filaggrin, fibrinogen, vimentin, and collagen. Presence of ACPA is associated with joint damage and extra-articular manifestations, suggesting that ACPAs are most likely pathogenic autoantibodies in RA. In vitro, ACPAs induce macrophage tumor necrosis factor alpha (TNF-?) production, osteoclastogenesis, and complement activation. These autoantibodies also induce the formation of neutrophil extracellular traps (NETs). Additionally, ACPAs induce pathogenic cytokines expression and oxidative stress in immune cells derived from RA patients. The aim of this review is to show the pathogenic roles of these autoantibodies in RA. Twit Text FOAVip ACPAs Are Much More Than Diagnostic Autoantibodies ????Rambam Maimonides Med J http://www.kidney.de/pget.php?&tw=1&pmid=27824549 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27824549 #FOAvip English Wikipedia <ref>{{Cite pmid|27824549 }}</ref> ACPAs Are Much More Than Diagnostic Autoantibodies #MMPMID27824549 Watad A ; Amital H Rambam Maimonides Med J 2016[Oct]; 7 (4 ): ä PMID27824549 show ga Anti-citrullinated protein autoantibodies (ACPAs) are the major autoantibodies in rheumatoid arthritis (RA). Anti-citrullinated protein autoantibodies are directed against different citrullinated antigens, including filaggrin, fibrinogen, vimentin, and collagen. Presence of ACPA is associated with joint damage and extra-articular manifestations, suggesting that ACPAs are most likely pathogenic autoantibodies in RA. In vitro, ACPAs induce macrophage tumor necrosis factor alpha (TNF-?) production, osteoclastogenesis, and complement activation. These autoantibodies also induce the formation of neutrophil extracellular traps (NETs). Additionally, ACPAs induce pathogenic cytokines expression and oxidative stress in immune cells derived from RA patients. The aim of this review is to show the pathogenic roles of these autoantibodies in RA. äACPAs Are Much More Than Diagnostic Autoantibodies (epmc).pdf DeepDyve Pubget Overpricing