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2015 ; 11
(5
): 1258-60
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A vaccine against Ebola: Problems and opportunities
#MMPMID25901415
Rezza G
Hum Vaccin Immunother
2015[]; 11
(5
): 1258-60
PMID25901415
show ga
The unprecedented dimensions of the 2014 Ebola epidemic which ravaged 3 West
African countries have challenged public health response capacity and urged the
availability of safe and effective vaccines. In this context, vectored vaccines
already tested in animal models have undergone phase 1 studies in human beings
and are now ready for efficacy evaluation in large scale trials. Health care
workers and other frontline caregivers are likely to be the target population for
both vaccine trials and vaccination campaigns. However, methodological and
ethical issues should be considered in plans concerning the conduction of
clinical trials and the possible use of licensed vaccines against Ebola.