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2014 ; 8
(8
): 1747-51
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A thermodynamic theory of microbial growth
#MMPMID24522260
Desmond-Le Quéméner E
; Bouchez T
ISME J
2014[Aug]; 8
(8
): 1747-51
PMID24522260
show ga
Our ability to model the growth of microbes only relies on empirical laws,
fundamentally restricting our understanding and predictive capacity in many
environmental systems. In particular, the link between energy balances and growth
dynamics is still not understood. Here we demonstrate a microbial growth equation
relying on an explicit theoretical ground sustained by Boltzmann statistics, thus
establishing a relationship between microbial growth rate and available energy.
The validity of our equation was then questioned by analyzing the microbial
isotopic fractionation phenomenon, which can be viewed as a kinetic consequence
of the differences in energy contents of isotopic isomers used for growth. We
illustrate how the associated theoretical predictions are actually consistent
with recent experimental evidences. Our work links microbial population dynamics
to the thermodynamic driving forces of the ecosystem, which opens the door to
many biotechnological and ecological developments.